GCK

Gene Symbol	GCK
Entrez Gene	2645
Alt Symbol	FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Species	Human
Gene Type	protein-coding
Description	glucokinase (hexokinase 4)
Other Description	ATP:D-hexose 6-phosphotransferase|HK IV|glucokinase|hexokinase D, pancreatic isozyme|hexokinase type IV|hexokinase-4|hexokinase-D
Swissprots	A4D2J2 A4D2J3 Q05810 P35557
Accessions	AAA67541 AAA67542 AAB97680 AAB97681 AAB97682 AGA96145 AGH08211 AGH08212 AGH08213 AGH08214 AGH08215 AGH08216 AGH08217 AGH08218 AGH08220 AGH08221 AGH08222 AGH08223 CBF63115 CBU87991 EAL23764 EAL23765 EAL23766 EAW61114 EAW61115 EAW61116 P35557 AK122876 BAG53774 BC001890 AAH01890 BT007062 AAP35711 CD251038 DA640823 DQ893835 ABM84761 EU008605 ABS31137 M69051 AAB59563 M88011 AAA51824 M90299 AAA52562 NM_000162 NP_000153 NM_033507 NP_277042 NM_033508 NP_277043
Function	Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:10456334}. Nucleus {ECO:0000269|PubMed:10456334}. Note=Under low glucose concentrations, GCK associates with GKRP and the inactive complex is recruited to the hepatocyte nucleus.
Tissue Specificity	Isoform 1 is expressed in pancreas. Isoform 2 and isoform 3 is expressed in liver.
Top Pathways	Glucagon signaling pathway, Central carbon metabolism in cancer, Insulin signaling pathway, Prolactin signaling pathway, Glycolysis / Gluconeogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Glucokinase (GCK) Human ELISA Kit - ab125967 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity 1.5 ng/ml Range 1.563 ng/ml - 50 ng/ml

Human GCK / Glucokinase ELISA Kit (Sandwich ELISA) - LS-F4838 from LifeSpan Bioscience Category ELISA Kit Prices $580.00 Sizes 1 plate Sensitivity 0.23 ng/ml Range 0.781-50 ng/ml

Rat GCK / Glucokinase ELISA Kit (Sandwich ELISA) - LS-F5875 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.24 ng/ml Range 0.781-50 ng/ml

Mouse GCK / Glucokinase ELISA Kit (Sandwich ELISA) - LS-F5874 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.781-50 ng/ml

Rat GCK / Glucokinase ELISA Kit (Sandwich ELISA) - LS-F11678 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 0.781-50 ng/ml

Human Glucokinase ELISA Kit - abx051803 from Abbexa Category ELISA Kit

Human Glucokinase ELISA Kit - abx151673 from Abbexa Category ELISA Kit Sensitivity 0.23 ng/ml Range 0.781 ng/ml - 50 ng/ml

Glucokinase, GCK, Human, ELISA Kit - E-EL-H1818 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.469 Range 0.781-50ng/mL

Glucokinase (GCK), Human, ELISA Kit - SEA667Hu from ARP American Research Products Category ELISA Kit Prices $580.00 Sizes 96 t Sensitivity 0.23ng/mL Range 0.78 -50ng/mL

Glucokinase, GCK, Human, ELISA Kit - CSB-E10442h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Glucokinase, GCK, Human, ELISA Kit - E0667h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

Glucokinase, Human, ELISA Kit - E01G0103 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 2.5-50ng/ml

Glucokinase, GCK, Mouse, ELISA Kit - E-EL-M0559 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Glucokinase, GCK, Rat, ELISA Kit - E-EL-R0426 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 0.375 Range 0.625-40ng/mL

Glucokinase, GCK, Rabbit, ELISA Kit - E-EL-RB2101 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Glucokinase, GCK, Chicken, ELISA Kit - E-EL-Ch1348 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Glucokinase, GCK, Porcine, ELISA Kit - E-EL-P0637 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Glucokinase, GCK, Sheep, ELISA Kit - E-EL-S0078 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t Sensitivity 0.188 Range 0.313-20ng/mL

Glucokinase, GCK, Monkey, ELISA Kit - E-EL-MK1886 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

GCK (Human) Matched Antibody Pair - H00002645-AP31 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

GCK (Human) Matched Antibody Pair - H00002645-AP51 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

GCK (Human) Matched Antibody Pair - H00002645-AP52 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

GCK (Human) ELISA Kit - KA2109 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Human GCK ELISA Kit - HG0110 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine GCK ELISA Kit - AG0110 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

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