| Gene Symbol |
AMN
|
| Entrez Gene |
81693
|
| Alt Symbol |
PRO1028, amnionless
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
amnion associated transmembrane protein
|
| Other Description |
amnionless homolog|protein amnionless|visceral endoderm-specific type 1 transmembrane protein
|
| Swissprots |
Q9BXJ7 Q6UX83
|
| Accessions |
EAW81798 EAW81799 Q9BXJ7 AF328788 AAK28532 AK055802 BAG51576 AY358468 AAQ89949 BC029948 CB306421 XM_011537202 XP_011535504 XM_011537203 XP_011535505 NM_030943 NP_112205
|
| Function |
Necessary for efficient absorption of vitamin B12. May direct the production of trunk mesoderm during development by modulating a bone morphogenetic protein (BMP) signaling pathway in the underlying visceral endoderm (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Long isoforms are highly expressed in small intestine, colon and kidney (renal proximal tubule epithelial cells). Shorter isoforms are detected at lower levels in testis, thymus and peripheral blood leukocytes. {ECO:0000269|PubMed:12590260, ECO:0000269|PubMed:14576052}.
|