| Gene Symbol | RPTOR |
|---|---|
| Entrez Gene | 57521 |
| Alt Symbol | KOG1, Mip1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | regulatory associated protein of MTOR, complex 1 |
| Other Description | p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats|raptor|regulatory-associated protein of mTOR |
| Swissprots | Q8TB32 C6KEF2 B2RN36 Q9P2P3 F5H7J5 Q8N4V9 Q8N122 |
| Accessions | EAW89618 EAW89619 Q8N122 AB037724 BAA92541 AB082951 BAC06490 AI821182 AK055912 AK295964 BAG58742 AK296321 BAH12314 AY090663 AAM09075 BC014502 BC025180 AAH25180 BC033258 AAH33258 BC033699 BC041079 BC064515 AAH64515 BC073898 AAH73898 BC136652 AAI36653 BC136654 AAI36655 BF111734 GQ183898 ACS44766 NM_001163034 NP_001156506 NM_020761 NP_065812 |
| Function | Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylati |
| Subcellular Location | Cytoplasm. Lysosome. Cytoplasmic granule. Note=Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased. |
| Tissue Specificity | Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta. Isoform 3 is widely expressed, with highest levels in nasal mucosa and pituitary and lowest in spleen. {ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12408816}. |
| Top Pathways | Insulin signaling pathway, PI3K-Akt signaling pathway, MicroRNAs in cancer, AMPK signaling pathway, mTOR signaling pathway |