RPTOR

Gene Symbol	RPTOR
Entrez Gene	57521
Alt Symbol	KOG1, Mip1
Species	Human
Gene Type	protein-coding
Description	regulatory associated protein of MTOR, complex 1
Other Description	p150 target of rapamycin (TOR)-scaffold protein containing WD-repeats|raptor|regulatory-associated protein of mTOR
Swissprots	Q8TB32 C6KEF2 B2RN36 Q9P2P3 F5H7J5 Q8N4V9 Q8N122
Accessions	EAW89618 EAW89619 Q8N122 AB037724 BAA92541 AB082951 BAC06490 AI821182 AK055912 AK295964 BAG58742 AK296321 BAH12314 AY090663 AAM09075 BC014502 BC025180 AAH25180 BC033258 AAH33258 BC033699 BC041079 BC064515 AAH64515 BC073898 AAH73898 BC136652 AAI36653 BC136654 AAI36655 BF111734 GQ183898 ACS44766 NM_001163034 NP_001156506 NM_020761 NP_065812
Function	Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylati
Subcellular Location	Cytoplasm. Lysosome. Cytoplasmic granule. Note=Targeting to lysosomes depends on amino acid availability. In arsenite-stressed cells, accumulates in stress granules when associated with SPAG5 and association with lysosomes is drastically decreased.
Tissue Specificity	Highly expressed in skeletal muscle, and in a lesser extent in brain, lung, small intestine, kidney and placenta. Isoform 3 is widely expressed, with highest levels in nasal mucosa and pituitary and lowest in spleen. {ECO:0000269|PubMed:12150925, ECO:0000269|PubMed:12408816}.
Top Pathways	Insulin signaling pathway, PI3K-Akt signaling pathway, MicroRNAs in cancer, AMPK signaling pathway, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Raptor full length protein - ab112419 from Abcam Category Protein Source Wheat germ Species Human

Human Raptor peptide - ab39860 from Abcam Category Peptide Species Human

Human Raptor protein fragment - ab153454 from Abcam Category Protein Source Wheat germ Species Human

Mouse Raptor peptide - ab39857 from Abcam Category Peptide Species Mouse

Raptor / Mip1 Antibody Blocking Peptide - LS-E30132 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Raptor / Mip1 Antibody Blocking Peptide - LS-E30133 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Raptor / Mip1 Antibody Blocking Peptide - LS-E30134 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Raptor / Mip1 Antibody Blocking Peptide - LS-E7402 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RPTOR Protein - H00057521-P01 from Novus Biologicals Category Protein Prices $319.00, $369.00, $529.00 Sizes 2 µg, 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human RPTOR Protein - H00057521-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RPTOR Peptide - NBP1-77212PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

RPTOR Blocking Peptide - NBP1-77211PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RPTOR Peptide - P1628 from Novus Biologicals Category Peptide Species Human

Phospho-RaptorS863-Antibody-Blocking-peptide - BP3495a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

RAPTOR - H00057521-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RAPTOR - H00057521-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RAPTOR - H00057521-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RAPTOR - H00057521-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RAPTOR Control Peptide - AP30709CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

RAPTOR Control Peptide - AP30710CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

KIAA1303 fusion protein - ag18128 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

KIAA1303 fusion protein - ag19389 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human RPTOR - RPTOR-30506TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human Regulatory-associated protein of mTOR(RPTOR) ,partial - CSB-YP839774HU CSB-EP839774HU CSB-BP839774HU CSB-MP839774HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RPTOR Protein - abx164969 from Abbexa Category Protein Species Human, Rat

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