Gene Symbol |
TIA1
|
Entrez Gene |
7072
|
Alt Symbol |
TIA-1, WDM
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
TIA1 cytotoxic granule-associated RNA binding protein
|
Other Description |
T-cell-restricted intracellular antigen-1|nucleolysin TIA-1 isoform p40|p40-TIA-1 (containing p15-TIA-1)
|
Swissprots |
P31483 Q96B58 Q53SS9
|
Accessions |
AAD14053 AAX93193 EAW99823 EAW99824 EAW99825 EAW99826 EAW99827 P31483 AB209211 BAD92448 AK093744 AK303345 BAG64407 BC015944 AAH15944 BM146739 CN295707 CX867570 DB136383 DR157578 M77142 XM_005264527 XP_005264584 XM_005264528 XP_005264585 XM_005264531 XP_005264588 XM_011533077 XP_011531379 XM_011533078 XP_011531380 XM_011533079 XP_011531381 XM_011533080 XP_011531382 XM_011533081 XP_011531383 XM_011533082 XP_011531384 XM_011533083 XP_011531385 XR_244955 XR_939714 XR_939715 NM_022037 NP_071320 NM_022173 NP_071505
|
Function |
Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.
|
Subcellular Location |
Cytoplasmic granule. Nucleus. Note=Accumulates in cytoplasmic stress granules (SG) following cellular damage.
|