Gene Symbol | TIA1 |
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Entrez Gene | 7072 |
Alt Symbol | TIA-1, WDM |
Species | Human |
Gene Type | protein-coding |
Description | TIA1 cytotoxic granule-associated RNA binding protein |
Other Description | T-cell-restricted intracellular antigen-1|nucleolysin TIA-1 isoform p40|p40-TIA-1 (containing p15-TIA-1) |
Swissprots | P31483 Q96B58 Q53SS9 |
Accessions | AAD14053 AAX93193 EAW99823 EAW99824 EAW99825 EAW99826 EAW99827 P31483 AB209211 BAD92448 AK093744 AK303345 BAG64407 BC015944 AAH15944 BM146739 CN295707 CX867570 DB136383 DR157578 M77142 XM_005264527 XP_005264584 XM_005264528 XP_005264585 XM_005264531 XP_005264588 XM_011533077 XP_011531379 XM_011533078 XP_011531380 XM_011533079 XP_011531381 XM_011533080 XP_011531382 XM_011533081 XP_011531383 XM_011533082 XP_011531384 XM_011533083 XP_011531385 XR_244955 XR_939714 XR_939715 NM_022037 NP_071320 NM_022173 NP_071505 |
Function | Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3' untranslated regions (3' UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. |
Subcellular Location | Cytoplasmic granule. Nucleus. Note=Accumulates in cytoplasmic stress granules (SG) following cellular damage. |
TIA-1 CRISPR/Cas9 KO Plasmid (h) - sc-400212 from Santa Cruz Biotechnology
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TIA-1 HDR Plasmid (h) - sc-400212-HDR from Santa Cruz Biotechnology
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TIA-1 Double Nickase Plasmid (h) - sc-400212-NIC from Santa Cruz Biotechnology
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TIA-1 Double Nickase Plasmid (h2) - sc-400212-NIC-2 from Santa Cruz Biotechnology
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TIA-1 CRISPR Activation Plasmid (h) - sc-400212-ACT from Santa Cruz Biotechnology
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TIA-1 CRISPR Activation Plasmid (h2) - sc-400212-ACT-2 from Santa Cruz Biotechnology
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TIA-1 Lentiviral Activation Particles (h) - sc-400212-LAC from Santa Cruz Biotechnology
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TIA-1 Lentiviral Activation Particles (h2) - sc-400212-LAC-2 from Santa Cruz Biotechnology
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TIA-1 siRNA (h) - sc-29504 from Santa Cruz Biotechnology
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TIA-1 shRNA Plasmid (h) - sc-29504-SH from Santa Cruz Biotechnology
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TIA-1 shRNA (h) Lentiviral Particles - sc-29504-V from Santa Cruz Biotechnology
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TIA1 RNAi - H00007072-R01 from Novus Biologicals
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TIA1 RNAi - H00007072-R02 from Novus Biologicals
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MISSION® esiRNA - EHU050801 from Sigma-Aldrich
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MISSION® esiRNA - EHU158111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21337 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21337 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07794 from Sigma-Aldrich
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TIA1 siRNA (Human) - CRH4841 from Cohesion Biosciences
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TIA1 - MBS8215837 from MyBioSource
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shRNA set against Human TIA1 (NM_022037.2) - SHH427180 from Creative biogene
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TIA1 shRNA Plasmid (Human) - CHH4841 from Cohesion Biosciences
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TIA1 miRNA 3'UTR clone - MiUTR4H-TG12612 from Creative biogene
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