| Gene Symbol |
SNRPF
|
| Entrez Gene |
6636
|
| Alt Symbol |
SMF, Sm-F, snRNP-F
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
small nuclear ribonucleoprotein polypeptide F
|
| Other Description |
sm protein F|small nuclear ribonucleoprotein F
|
| Swissprots |
B2R498 Q6IBQ1 Q6P4I0 P62306 A2VCR2
|
| Accessions |
EAW97548 EAW97549 P62306 AK311752 BAG34695 BC002505 AAH02505 BC063397 AAH63397 BC128452 AAI28453 BC128453 AAI28454 BM972965 BU861031 CR456751 CAG33032 X85372 CAA59688 NM_003095 NP_003086
|
| Function |
Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
|
| Top Pathways |
Spliceosome
|
![Western Blot: SNRPF Overexpression Lysate (Adult Normal) [NBL1-16293] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SNRPF.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8981_SNRPF%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16293-img0002.jpg)