Gene Symbol | SNRPF |
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Entrez Gene | 6636 |
Alt Symbol | SMF, Sm-F, snRNP-F |
Species | Human |
Gene Type | protein-coding |
Description | small nuclear ribonucleoprotein polypeptide F |
Other Description | sm protein F|small nuclear ribonucleoprotein F |
Swissprots | B2R498 Q6IBQ1 Q6P4I0 P62306 A2VCR2 |
Accessions | EAW97548 EAW97549 P62306 AK311752 BAG34695 BC002505 AAH02505 BC063397 AAH63397 BC128452 AAI28453 BC128453 AAI28454 BM972965 BU861031 CR456751 CAG33032 X85372 CAA59688 NM_003095 NP_003086 |
Function | Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in an heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. {ECO:0000269|PubMed:18984161, ECO:0000269|PubMed:23333303}. |
Subcellular Location | Cytoplasm, cytosol {ECO:0000269|PubMed:18984161}. Nucleus {ECO:0000269|PubMed:18984161}. Note=SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes. |
Top Pathways | Spliceosome |
Sm F CRISPR/Cas9 KO Plasmid (h) - sc-418208 from Santa Cruz Biotechnology
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Sm F HDR Plasmid (h) - sc-418208-HDR from Santa Cruz Biotechnology
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Sm F Double Nickase Plasmid (h) - sc-418208-NIC from Santa Cruz Biotechnology
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Sm F Double Nickase Plasmid (h2) - sc-418208-NIC-2 from Santa Cruz Biotechnology
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Sm F CRISPR Activation Plasmid (h) - sc-418208-ACT from Santa Cruz Biotechnology
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Sm F CRISPR Activation Plasmid (h2) - sc-418208-ACT-2 from Santa Cruz Biotechnology
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Sm F Lentiviral Activation Particles (h) - sc-418208-LAC from Santa Cruz Biotechnology
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Sm F Lentiviral Activation Particles (h2) - sc-418208-LAC-2 from Santa Cruz Biotechnology
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Sm F siRNA (h) - sc-38331 from Santa Cruz Biotechnology
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Sm F shRNA Plasmid (h) - sc-38331-SH from Santa Cruz Biotechnology
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Sm F shRNA (h) Lentiviral Particles - sc-38331-V from Santa Cruz Biotechnology
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SNRPF RNAi - H00006636-R01 from Novus Biologicals
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MISSION® esiRNA - EHU112301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20275 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20275 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03663 from Sigma-Aldrich
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SNRPF siRNA (Human) - CRH4518 from Cohesion Biosciences
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SNRPF - MBS8230261 from MyBioSource
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shRNA set against Human SNRPF (NM_003095.2) - SHH414408 from Creative biogene
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SNRPF shRNA Plasmid (Human) - CHH4518 from Cohesion Biosciences
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SNRPF miRNA 3'UTR clone - MiUTR1H-09702 from Creative biogene
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