| Gene Symbol | ST8SIA1 |
|---|---|
| Entrez Gene | 6489 |
| Alt Symbol | GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI |
| Species | Human |
| Gene Type | protein-coding |
| Description | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 |
| Other Description | alpha-2,8-sialyltransferase 8A|alpha-N-acetylneuraminide alpha-2,8-sialyltransferase|disialoganglioside (GD3) synthase|ganglioside GD3 synthase|ganglioside GT3 synthase|ganglioside-specific alpha-2,8-polysialyltransferase|sialyltransferase 8 (alpha-N-acetylneuraminate: alpha-2,8-sialytransferase, GD3 synthase) A|sialyltransferase 8A (alpha-N-acetylneuraminate: alpha-2,8-sialyltransferase, GD3 synthase)|sialyltransferase St8Sia I|sialytransferase St8Sia I |
| Swissprots | Q93064 Q92185 Q17RL0 A8K4H6 Q6PZN5 |
| Accessions | CAS91695 EAW96468 EAW96469 EAW96470 EAW96471 Q92185 AF088002 AK290941 BAF83630 AK297310 BAG59776 AK315340 BAG37739 AY569975 AAS75783 BC031081 BC046158 AAH46158 BC117285 AAI17286 BC126162 AAI26163 BM929838 D26360 BAA05391 EU041716 ABU62753 HQ258201 ADR82955 L32867 AAA62366 L43494 AAC37586 X77922 CAA54891 XM_005253470 XP_005253527 XM_011520817 XP_011519119 XR_931322 NM_001304450 NP_001291379 NM_003034 NP_003025 |
| Function | Involved in the production of gangliosides GD3 and GT3 from GM3; gangliosides are a subfamily of complex glycosphinglolipds that contain one or more residues of sialic acid. {ECO:0000269|PubMed:7937974, ECO:0000269|PubMed:8058740, ECO:0000269|PubMed:8195250, ECO:0000269|PubMed:8631981}. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. |
| Tissue Specificity | Strongly expressed in melanoma cell lines, adult and fetal brain and to a lesser extent in adult and fetal lung. {ECO:0000269|PubMed:7937974, ECO:0000269|PubMed:8631981}. |
| Top Pathways | Glycosphingolipid biosynthesis - globo series, Glycosphingolipid biosynthesis - lacto and neolacto series, Glycosphingolipid biosynthesis - ganglio series |
GD3 Synthase CRISPR/Cas9 KO Plasmid (h) - sc-404015 from Santa Cruz Biotechnology
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GD3 Synthase HDR Plasmid (h) - sc-404015-HDR from Santa Cruz Biotechnology
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GD3 Synthase Double Nickase Plasmid (h) - sc-404015-NIC from Santa Cruz Biotechnology
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GD3 Synthase Double Nickase Plasmid (h2) - sc-404015-NIC-2 from Santa Cruz Biotechnology
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GD3 Synthase CRISPR Activation Plasmid (h) - sc-404015-ACT from Santa Cruz Biotechnology
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GD3 Synthase CRISPR Activation Plasmid (h2) - sc-404015-ACT-2 from Santa Cruz Biotechnology
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GD3 Synthase Lentiviral Activation Particles (h) - sc-404015-LAC from Santa Cruz Biotechnology
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GD3 Synthase Lentiviral Activation Particles (h2) - sc-404015-LAC-2 from Santa Cruz Biotechnology
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GD3 synthase siRNA (h) - sc-44586 from Santa Cruz Biotechnology
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GD3 synthase shRNA Plasmid (h) - sc-44586-SH from Santa Cruz Biotechnology
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GD3 synthase shRNA (h) Lentiviral Particles - sc-44586-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU025731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20674 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20674 from Sigma-Aldrich
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ST8SIA1 siRNA (Human) - CRH4385 from Cohesion Biosciences
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ST8SIA1 - MBS8216905 from MyBioSource
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shRNA set against Human ST8SIA1 (NM_003034.3) - SHH419004 from Creative biogene
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shRNA set against Human ST8SIA1(NM_003034.3) - SHL038916 from Creative biogene
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ST8SIA1 shRNA Plasmid (Human) - CHH4385 from Cohesion Biosciences
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ST8SIA1 miRNA 3'UTR clone - MiUTR1H-09958 from Creative biogene
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