Gene Symbol |
NUAK2
|
Entrez Gene |
81788
|
Alt Symbol |
SNARK
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
NUAK family, SNF1-like kinase, 2
|
Other Description |
NUAK family SNF1-like kinase 2|SNF1/AMP activated protein kinase|SNF1/AMP kinase-related kinase|omphalocele kinase 2
|
Swissprots |
Q9H093
|
Accessions |
CAF86008 EAW91549 Q9H093 AK074830 BAC11234 AK303577 BAG64597 AK309520 AL136891 CAB66825 AM392904 CAL37782 BC017306 AAH17306 BX537564 CR749209 CAH18066 XM_005245515 XP_005245572 XM_011510029 XP_011508331 NM_030952 NP_112214
|
Function |
Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1. {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127}.
|