Gene Symbol | NUAK2 |
---|---|
Entrez Gene | 81788 |
Alt Symbol | SNARK |
Species | Human |
Gene Type | protein-coding |
Description | NUAK family, SNF1-like kinase, 2 |
Other Description | NUAK family SNF1-like kinase 2|SNF1/AMP activated protein kinase|SNF1/AMP kinase-related kinase|omphalocele kinase 2 |
Swissprots | Q9H093 |
Accessions | CAF86008 EAW91549 Q9H093 AK074830 BAC11234 AK303577 BAG64597 AK309520 AL136891 CAB66825 AM392904 CAL37782 BC017306 AAH17306 BX537564 CR749209 CAH18066 XM_005245515 XP_005245572 XM_011510029 XP_011508331 NM_030952 NP_112214 |
Function | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1. {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127}. |