Gene Symbol | NUAK2 |
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Entrez Gene | 81788 |
Alt Symbol | SNARK |
Species | Human |
Gene Type | protein-coding |
Description | NUAK family, SNF1-like kinase, 2 |
Other Description | NUAK family SNF1-like kinase 2|SNF1/AMP activated protein kinase|SNF1/AMP kinase-related kinase|omphalocele kinase 2 |
Swissprots | Q9H093 |
Accessions | CAF86008 EAW91549 Q9H093 AK074830 BAC11234 AK303577 BAG64597 AK309520 AL136891 CAB66825 AM392904 CAL37782 BC017306 AAH17306 BX537564 CR749209 CAH18066 XM_005245515 XP_005245572 XM_011510029 XP_011508331 NM_030952 NP_112214 |
Function | Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95- activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1. {ECO:0000269|PubMed:14575707, ECO:0000269|PubMed:14976552, ECO:0000269|PubMed:15345718, ECO:0000269|PubMed:19927127}. |
SNARK CRISPR/Cas9 KO Plasmid (h) - sc-405079 from Santa Cruz Biotechnology
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SNARK HDR Plasmid (h) - sc-405079-HDR from Santa Cruz Biotechnology
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SNARK Double Nickase Plasmid (h) - sc-405079-NIC from Santa Cruz Biotechnology
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SNARK Double Nickase Plasmid (h2) - sc-405079-NIC-2 from Santa Cruz Biotechnology
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SNARK CRISPR Activation Plasmid (h) - sc-405079-ACT from Santa Cruz Biotechnology
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SNARK CRISPR Activation Plasmid (h2) - sc-405079-ACT-2 from Santa Cruz Biotechnology
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SNARK Lentiviral Activation Particles (h) - sc-405079-LAC from Santa Cruz Biotechnology
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SNARK Lentiviral Activation Particles (h2) - sc-405079-LAC-2 from Santa Cruz Biotechnology
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SNARK siRNA (h) - sc-88608 from Santa Cruz Biotechnology
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SNARK shRNA Plasmid (h) - sc-88608-SH from Santa Cruz Biotechnology
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SNARK shRNA (h) Lentiviral Particles - sc-88608-V from Santa Cruz Biotechnology
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NUAK2 RNAi - H00081788-R02 from Novus Biologicals
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MISSION® esiRNA - EHU043791 from Sigma-Aldrich
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MISSION® siRNA - SIHK1469 from Sigma-Aldrich
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MISSION® siRNA - SIHK1470 from Sigma-Aldrich
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MISSION® siRNA - SIHK1468 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15575 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15575 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09515 from Sigma-Aldrich
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NUAK2 siRNA (Human) - CRJ3048 from Cohesion Biosciences
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SNARK CRISPR/Cas9 KO Plasmid (h2) - sc-405079-KO-2 from Santa Cruz Biotechnology
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SNARK HDR Plasmid (h2) - sc-405079-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human NUAK2 (NM_030952.1) - SHH355864 from Creative biogene
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shRNA set against Human NUAK2(NM_030952.1) - SHR009294 from Creative biogene
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Human NUAK2 siRNA - orb273549 from Biorbyt
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