Gene Symbol | ENC1 |
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Entrez Gene | 8507 |
Alt Symbol | CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10 |
Species | Human |
Gene Type | protein-coding |
Description | ectodermal-neural cortex 1 (with BTB domain) |
Other Description | ectoderm-neural cortex protein 1|ectodermal-neural cortex 1 (with BTB-like domain)|kelch-like 35|kelch-like family member 37|kelch-like protein 37|nuclear matrix protein NRP/B|nuclear restricted protein, BTB domain-like (brain)|p53-induced gene 10 protein|tumor protein p53 inducible protein 10 |
Swissprots | O75464 E9PFU0 O14682 B4DHJ1 Q9UPG9 |
Accessions | EAW95740 O14682 AF005381 AAC64498 AF010314 AAC39532 AF059611 AAC26109 AK096578 BAG53327 AK295128 BAG58153 AK299624 BAG61552 AK312608 BAG35496 AU120246 AY049781 AAL15438 BC000418 AAH00418 BT007392 AAP36056 DA032687 DA498140 DA785554 DQ891845 ABM82771 DQ895033 ABM85959 EU831625 ACE87225 EU831710 ACE86544 XM_011543696 XP_011541998 XM_011543697 XP_011541999 NM_001256574 NP_001243503 NM_001256575 NP_001243504 NM_001256576 NP_001243505 NM_003633 NP_003624 NR_046318 |
Function | Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism. {ECO:0000269|PubMed:19424503}. |
Subcellular Location | Nucleus matrix {ECO:0000269|PubMed:19424503}. Cytoplasm {ECO:0000269|PubMed:19424503}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19424503}. |
Tissue Specificity | Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas. May be down- regulated in neuroblastoma tumors. |
Human ENC1 full length protein - ab132598 from Abcam
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ENC1 Antibody Blocking Peptide - LS-E4734 from LifeSpan Bioscience
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ENC1 Antibody Blocking Peptide - LS-E12096 from LifeSpan Bioscience
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ENC1 Antibody Blocking Peptide - LS-E30904 from LifeSpan Bioscience
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ENC1 Antibody Blocking Peptide - LS-E27991 from LifeSpan Bioscience
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Recombinant Human ENC1 Protein - H00008507-P01 from Novus Biologicals
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Recombinant Human ENC1 Protein - H00008507-Q01 from Novus Biologicals
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ENC1 Blocking Peptide - NBP1-77146PEP from Novus Biologicals
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ENC1-Antibody-C-term-Blocking-Peptide - BP17107b from Abgent, a WuXi AppTec company
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ENC1 Peptide - GTX85108-PEP from GeneTex
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ENC1 Peptide - AC21-2753-P from Abcore
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ENC1 - H00008507-P01-10 from Acris Antibodies
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ENC1 - H00008507-P01-25 from Acris Antibodies
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ENC1 - H00008507-Q01-10 from Acris Antibodies
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ENC1 - H00008507-Q01-25 from Acris Antibodies
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ENC-1 Peptide - 5693P from ProSci
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ENC1 fusion protein - ag6607 from Proteintech Group
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ENC1 fusion protein - ag6510 from Proteintech Group
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Recombinant Human ENC1, His-tagged - ENC1-28558TH from Creative Biomart
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Recombinant Human Ectoderm-neural cortex protein 1(ENC1) - CSB-YP007663HU CSB-EP007663HU CSB-BP007663HU CSB-MP007663HU from Cusabio
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ENC1 - TP301842 from Acris Antibodies
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ENC1, Peptide - MBS427774 from MyBioSource
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ENC1 Peptide, Human - M34GP04927H from Creative Peptides
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Ectoderm-neural cortex protein 1 (ENC1), Recombinant Protein - MBS1152724 from MyBioSource
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ENC1 Immunizing peptide - orb66460 from Biorbyt
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