Gene Symbol | ENC1 |
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Entrez Gene | 8507 |
Alt Symbol | CCL28, ENC-1, KLHL35, KLHL37, NRPB, PIG10, TP53I10 |
Species | Human |
Gene Type | protein-coding |
Description | ectodermal-neural cortex 1 (with BTB domain) |
Other Description | ectoderm-neural cortex protein 1|ectodermal-neural cortex 1 (with BTB-like domain)|kelch-like 35|kelch-like family member 37|kelch-like protein 37|nuclear matrix protein NRP/B|nuclear restricted protein, BTB domain-like (brain)|p53-induced gene 10 protein|tumor protein p53 inducible protein 10 |
Swissprots | O75464 E9PFU0 O14682 B4DHJ1 Q9UPG9 |
Accessions | EAW95740 O14682 AF005381 AAC64498 AF010314 AAC39532 AF059611 AAC26109 AK096578 BAG53327 AK295128 BAG58153 AK299624 BAG61552 AK312608 BAG35496 AU120246 AY049781 AAL15438 BC000418 AAH00418 BT007392 AAP36056 DA032687 DA498140 DA785554 DQ891845 ABM82771 DQ895033 ABM85959 EU831625 ACE87225 EU831710 ACE86544 XM_011543696 XP_011541998 XM_011543697 XP_011541999 NM_001256574 NP_001243503 NM_001256575 NP_001243504 NM_001256576 NP_001243505 NM_003633 NP_003624 NR_046318 |
Function | Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin- mediated proteasomal degradation mechanism. {ECO:0000269|PubMed:19424503}. |
Subcellular Location | Nucleus matrix {ECO:0000269|PubMed:19424503}. Cytoplasm {ECO:0000269|PubMed:19424503}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:19424503}. |
Tissue Specificity | Detected in fetal brain tissue, moderate expression in fetal heart, lung and kidney. Highly expressed in adult brain, particularly high in the hippocampus and amygdala, and spinal chord. Detectable in adult pancreas. May be down- regulated in neuroblastoma tumors. |
ENC1 CRISPR/Cas9 KO Plasmid (h) - sc-406167 from Santa Cruz Biotechnology
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ENC1 HDR Plasmid (h) - sc-406167-HDR from Santa Cruz Biotechnology
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ENC1 Double Nickase Plasmid (h) - sc-406167-NIC from Santa Cruz Biotechnology
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ENC1 Double Nickase Plasmid (h2) - sc-406167-NIC-2 from Santa Cruz Biotechnology
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ENC1 CRISPR Activation Plasmid (h) - sc-406167-ACT from Santa Cruz Biotechnology
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ENC1 CRISPR Activation Plasmid (h2) - sc-406167-ACT-2 from Santa Cruz Biotechnology
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ENC1 Lentiviral Activation Particles (h) - sc-406167-LAC from Santa Cruz Biotechnology
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ENC1 Lentiviral Activation Particles (h2) - sc-406167-LAC-2 from Santa Cruz Biotechnology
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ENC1 siRNA (h) - sc-91870 from Santa Cruz Biotechnology
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ENC1 shRNA Plasmid (h) - sc-91870-SH from Santa Cruz Biotechnology
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ENC1 shRNA (h) Lentiviral Particles - sc-91870-V from Santa Cruz Biotechnology
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ENC1 RNAi - H00008507-R01 from Novus Biologicals
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MISSION® esiRNA - EHU011301 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7864 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7864 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR11686 from Sigma-Aldrich
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ENC1 siRNA (Human) - CRH5581 from Cohesion Biosciences
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ENC1 - MBS8229503 from MyBioSource
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shRNA set against Human ENC1 (NM_003633.3) - SHH285725 from Creative biogene
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ENC1 CRISPR/Cas9 KO Plasmid (h2) - sc-406167-KO-2 from Santa Cruz Biotechnology
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ENC1 HDR Plasmid (h2) - sc-406167-HDR-2 from Santa Cruz Biotechnology
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Human ENC1 siRNA - orb266083 from Biorbyt
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ENC1 shRNA Plasmid (Human) - CHH5581 from Cohesion Biosciences
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ENC1 miRNA 3'UTR clone - MiUTR4H-TG03081 from Creative biogene
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