| Gene Symbol |
ZNF521
|
| Entrez Gene |
25925
|
| Alt Symbol |
EHZF, Evi3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger protein 521
|
| Other Description |
LYST-interacting protein 3|early hematopoietic zinc finger protein
|
| Swissprots |
Q96K83 B0YJB7 Q8TES6 Q9C065 Q8IXI0 Q9HAL5 Q9UFK4
|
| Accessions |
ACA06095 EAX01201 Q96K83 AF141339 AAG49442 AJ518106 CAD57322 AK021452 BAB13829 AK027354 BAB55056 AK074046 BAB84872 AK293067 BAF85756 AL117615 CAB56016 BC032869 AAH32869 BC113622 AAI13623 BC113648 AAI13649 BC143727 CA415157 DA102816 XM_005258241 XP_005258298 XM_011525909 XP_011524211 XM_011525910 XP_011524212 XM_011525911 XP_011524213 NM_001308225 NP_001295154 NM_015461 NP_056276
|
| Function |
Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. {ECO:0000269|PubMed:14630787}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins. {ECO:0000269|PubMed:14630787}.
|
