ZNF521

Gene Symbol ZNF521
Entrez Gene 25925
Alt Symbol EHZF, Evi3
Species Human
Gene Type protein-coding
Description zinc finger protein 521
Other Description LYST-interacting protein 3|early hematopoietic zinc finger protein
Swissprots Q96K83 B0YJB7 Q8TES6 Q9C065 Q8IXI0 Q9HAL5 Q9UFK4
Accessions ACA06095 EAX01201 Q96K83 AF141339 AAG49442 AJ518106 CAD57322 AK021452 BAB13829 AK027354 BAB55056 AK074046 BAB84872 AK293067 BAF85756 AL117615 CAB56016 BC032869 AAH32869 BC113622 AAI13623 BC113648 AAI13649 BC143727 CA415157 DA102816 XM_005258241 XP_005258298 XM_011525909 XP_011524211 XM_011525910 XP_011524212 XM_011525911 XP_011524213 NM_001308225 NP_001295154 NM_015461 NP_056276
Function Transcription factor that can both act as an activator or a repressor depending on the context. Involved in BMP signaling and in the regulation of the immature compartment of the hematopoietic system. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved specification of B-cell lineage; this interaction preventing EBF1 to bind DNA and activate target genes. {ECO:0000269|PubMed:14630787}.
Subcellular Location Nucleus {ECO:0000250}.
Tissue Specificity Predominantly expressed in hematopoietic cells. Present in organs and tissues that contain stem and progenitor cells, myeloid and/or lymphoid: placenta, spleen, lymph nodes, thymus, bone marrow and fetal liver. Within the hematopoietic system, it is abundant in CD34(+) cells but undetectable in mature peripheral blood leukocytes, and its levels rapidly decrease during the differentiation of CD34(+) cells in response to hemopoietins. {ECO:0000269|PubMed:14630787}.

EHZF CRISPR/Cas9 KO Plasmid (h) - sc-404324 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHZF HDR Plasmid (h) - sc-404324-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHZF Double Nickase Plasmid (h) - sc-404324-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHZF Double Nickase Plasmid (h2) - sc-404324-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHZF CRISPR Activation Plasmid (h) - sc-404324-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHZF CRISPR Activation Plasmid (h2) - sc-404324-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHZF Lentiviral Activation Particles (h) - sc-404324-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHZF Lentiviral Activation Particles (h2) - sc-404324-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

EHZF siRNA (h) - sc-77245 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EHZF shRNA Plasmid (h) - sc-77245-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

EHZF shRNA (h) Lentiviral Particles - sc-77245-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ZNF521 RNAi - H00025925-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU126721 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN23512 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23512 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06599 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06599

ZNF521 siRNA (Human) - CRH8592 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZNF521 - MBS8218682 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ZNF521 (NM_015461.2) - SHH454252 from Creative biogene

Category siRNA
Species Reactivities Human

Human ZNF521 siRNA - orb269094 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZNF521 shRNA Plasmid (Human) - CHH8592 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ZNF521 miRNA 3'UTR clone - MiUTR3H-11581 from Creative biogene

Species Reactivities Human
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