GRK5

Gene Symbol	GRK5
Entrez Gene	2869
Alt Symbol	GPRK5
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor kinase 5
Other Description	FP2025|g protein-coupled receptor kinase GRK5
Swissprots	Q5T059 D3DRD0 P34947
Accessions	CBX53840 EAW49393 EAW49394 EAW49395 P34947 AF370369 AAQ15205 AK097099 AK298261 BAG60525 AK301450 BAG62974 AK309761 AK313012 BAG35847 BC018116 BC064506 AAH64506 BC114448 AAI14449 BQ184611 CN290123 L15388 AAA58620 XM_005269707 XP_005269764 XM_005269708 XP_005269765 XM_011539699 XP_011538001 NM_005308 NP_005299
Function	Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein- coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70- interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2- mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of
Subcellular Location	Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion.
Tissue Specificity	Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney. {ECO:0000269|PubMed:7685906}.
Top Pathways	Endocytosis, Chemokine signaling pathway, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat GRK5 ELISA Kit (Cell-Based ELISA) - LS-F3088 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.312-20 ng/ml

G protein-coupled receptor kinase 5 (GRK5), Human, ELISA Kit - CSB-EL009926HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

GRK5 Colorimetric Cell-Based ELISA - CB5877 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

G protein-coupled receptor kinase 5, ELISA Kit - MBS909001 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 7 pg/ml Range 28 pg/ml-1800 pg/ml.

Human G protein-coupled receptor kinase 5(GRK5) ELISA kit - CSB-EL009926HU from Cusabio Category ELISA Kit Sensitivity 7pg/ml Range 28 pg/ml-1800 pg/ml

GRK5 ELISA Kit - DEIA-XYA757 from Creative Diagnostics Category ELISA Kit

Custom Human GRK5 ELISA - ELH-GRK5-1 from RayBiotech Category ELISA Kit Prices $627.00, $1,128.60, $2,508.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit

Custom Human GRK5 ELISA Kit - orb384612 from Biorbyt Category ELISA Kit Prices $1,411.00, $2,448.00, $5,321.00 Sizes 96 assays, 192 assays, 480 assays

Human GRK5 ELISA Kit - E015848 from Biobool Category ELISA Kit Sensitivity Typically less than 7 pg/ml

GRK5 ELISA Kit (Human) (OKCA00679) - OKCA00679 from Aviva Systems Biology Category ELISA Kit Prices $590.00 Sizes 96 wells Sensitivity 7 pg/mL Range 28 pg/mL-1,800 pg/mL

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9363753 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9352821 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9360757 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9353683 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9349470 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9352130 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9349240 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9354111 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9355947 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9346835 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9357769 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9369529 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9348363 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9360021 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

G Protein-Coupled Receptor Kinase 5 (GRK5), ELISA Kit - MBS9359790 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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