GRK5

Gene Symbol	GRK5
Entrez Gene	2869
Alt Symbol	GPRK5
Species	Human
Gene Type	protein-coding
Description	G protein-coupled receptor kinase 5
Other Description	FP2025|g protein-coupled receptor kinase GRK5
Swissprots	Q5T059 D3DRD0 P34947
Accessions	CBX53840 EAW49393 EAW49394 EAW49395 P34947 AF370369 AAQ15205 AK097099 AK298261 BAG60525 AK301450 BAG62974 AK309761 AK313012 BAG35847 BC018116 BC064506 AAH64506 BC114448 AAI14449 BQ184611 CN290123 L15388 AAA58620 XM_005269707 XP_005269764 XM_005269708 XP_005269765 XM_011539699 XP_011538001 NM_005308 NP_005299
Function	Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein- coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70- interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2- mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of
Subcellular Location	Cytoplasm. Nucleus. Cell membrane; Peripheral membrane protein. Note=Predominantly localized at the plasma membrane; targeted to the cell surface through the interaction with phospholipids. Nucleus localization is regulated in a GPCR and Ca(2+)/calmodulin-dependent fashion.
Tissue Specificity	Highest levels in heart, placenta, lung > skeletal muscle > brain, liver, pancreas > kidney. {ECO:0000269|PubMed:7685906}.
Top Pathways	Endocytosis, Chemokine signaling pathway, Morphine addiction

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human GRK5 full length protein - ab60862 from Abcam Category Protein Prices $294.00, $1,845.00 Sizes 10 µg, 100 µg Source Baculovirus infected sf9 cells Species Human

GRK5 Antibody Blocking Peptide - LS-E19736 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GRK5 Antibody Blocking Peptide - LS-E28760 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GRK5 Antibody Blocking Peptide - LS-E28740 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GRK5 Antibody Blocking Peptide - LS-E28673 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GRK5 Antibody Blocking Peptide - LS-E28672 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

GRK5 Antibody Blocking Peptide - LS-E8599 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

GRK5 Partial Recombinant Protein - H00002869-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

GRK5 Recombinant Protein - P4193 from Novus Biologicals Category Protein Prices $549.00 Sizes 5 µg Species Human

Recombinant Human GRK5 Protein - P3865 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 5 µg Source Insect Species Human

Recombinant GRK5 Protein - NBP1-99457 from Novus Biologicals Category Protein Prices $295.00 Sizes 5 µg Source Baculovirus (Sf9 insect cells)

GRK5 Peptide - P2090 from Novus Biologicals Category Peptide Species Human

GRK5-Antibody-C-term-Blocking-Peptide - BP7007a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GRK5 (Active) recombinant protein - GTX65107 from GeneTex Category Protein Prices $389.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

GRK5 peptide - orb217359 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

GRK5 Blocking Peptide - 33R-3133 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

GRK5 protein - 30R-2824 from Fitzgerald Category Protein Prices $425.00 Sizes 5 µg Source Sf-9 insect cells Species Human

GRK5 Blocking Peptide - abx062690 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine

Human GRK5 Protein - abx066710 from Abbexa Category Protein Source E.coli Species Human

GPRK5 - H00002869-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

GPRK5 - H00002869-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GPRK5 - P3865 from Acris Antibodies Category Protein Prices $1,230.00 Sizes 5 µg Species Human

GPRK5 - P4193 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

GRK5 fusion protein - Ag10511 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

GRK5 fusion protein - ag10535 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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