SMC1B
| Gene Symbol | SMC1B |
|---|---|
| Entrez Gene | 27127 |
| Alt Symbol | SMC1BETA, SMC1L2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | structural maintenance of chromosomes 1B |
| Other Description | SMC protein 1B|SMC1 (structural maintenance of chromosomes 1, yeast)-like 1|SMC1 structural maintenance of chromosomes 1-like 2|mitosis-specific chromosome segregation protein like protein beta|structural maintenance of chromosomes protein 1B |
| Swissprots | B0QY23 Q9Y3G5 Q8NDV3 A0AV46 Q6ZUF9 B0QY24 Q5TIC3 |
| Accessions | EAW73381 EAW73382 EAW73383 Q8NDV3 AJ504806 CAD43404 AK125736 BAC86266 AL704843 BC126208 AAI26209 BG194018 XM_011530144 XP_011528446 XM_011530145 XP_011528447 XM_011530146 XP_011528448 XR_244368 NM_001291501 NP_001278430 NM_148674 NP_683515 |
| Function | Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. Chromosome {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity). {ECO:0000250}. |
| Top Pathways | Cell cycle, Oocyte meiosis |
SMC1 CRISPR/Cas9 KO Plasmid (h) - sc-403715 from Santa Cruz Biotechnology
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SMC1 HDR Plasmid (h) - sc-403715-HDR from Santa Cruz Biotechnology
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SMC1 Double Nickase Plasmid (h) - sc-403715-NIC from Santa Cruz Biotechnology
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SMC1 Double Nickase Plasmid (h2) - sc-403715-NIC-2 from Santa Cruz Biotechnology
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SMC1 CRISPR Activation Plasmid (h) - sc-403715-ACT from Santa Cruz Biotechnology
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SMC1 CRISPR Activation Plasmid (h2) - sc-403715-ACT-2 from Santa Cruz Biotechnology
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SMC1 Lentiviral Activation Particles (h) - sc-403715-LAC from Santa Cruz Biotechnology
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SMC1 Lentiviral Activation Particles (h2) - sc-403715-LAC-2 from Santa Cruz Biotechnology
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SMC1 siRNA (h) - sc-63348 from Santa Cruz Biotechnology
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SMC1β shRNA Plasmid (h) - sc-63348-SH from Santa Cruz Biotechnology
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SMC1β shRNA (h) Lentiviral Particles - sc-63348-V from Santa Cruz Biotechnology
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SMC1L2 RNAi - H00027127-R01 from Novus Biologicals
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MISSION® esiRNA - EHU134481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19774 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19774 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04063 from Sigma-Aldrich
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SMC1B siRNA (Human) - CRH8980 from Cohesion Biosciences
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SMC1B - MBS8206914 from MyBioSource
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shRNA set against Human Smc1b (NM_148674.3) - SHH413240 from Creative biogene
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shRNA set against Human SMC1B(NM_148674.3) - SHL016230 from Creative biogene
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Human SMC1B siRNA - orb269482 from Biorbyt
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SMC1B shRNA Plasmid (Human) - CHH8980 from Cohesion Biosciences
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SMC1B miRNA 3'UTR clone - MiUTR3H-10152 from Creative biogene
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