SMC1B

Gene Symbol	SMC1B
Entrez Gene	27127
Alt Symbol	SMC1BETA, SMC1L2
Species	Human
Gene Type	protein-coding
Description	structural maintenance of chromosomes 1B
Other Description	SMC protein 1B\|SMC1 (structural maintenance of chromosomes 1, yeast)-like 1\|SMC1 structural maintenance of chromosomes 1-like 2\|mitosis-specific chromosome segregation protein like protein beta\|structural maintenance of chromosomes protein 1B
Swissprots	B0QY23 Q9Y3G5 Q8NDV3 A0AV46 Q6ZUF9 B0QY24 Q5TIC3
Accessions	EAW73381 EAW73382 EAW73383 Q8NDV3 AJ504806 CAD43404 AK125736 BAC86266 AL704843 BC126208 AAI26209 BG194018 XM_011530144 XP_011528446 XM_011530145 XP_011528447 XM_011530146 XP_011528448 XR_244368 NM_001291501 NP_001278430 NM_148674 NP_683515
Function	Meiosis-specific component of cohesin complex. Required for the maintenance of meiotic cohesion, but not, or only to a minor extent, for its establishment. Contributes to axial element (AE) formation and the organization of chromatin loops along the AE. Plays a key role in synapsis, recombination and chromosome movements. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The meiosis-specific cohesin complex probably replaces mitosis specific cohesin complex when it dissociates from chromatin during prophase I (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus. Chromosome {ECO:0000250}. Chromosome, centromere {ECO:0000250}. Note=Associates with chromatin. In prophase I stage of meiosis, localizes along the AE of synaptonemal complexes. In late-pachytene-diplotene, the bulk of protein dissociates from the chromosome arms probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. Remains chromatin associated at the centromeres up to metaphase II. At anaphase II, dissociates from centromeres, allowing chromosomes segregation (By similarity). {ECO:0000250}.
Top Pathways	Cell cycle, Oocyte meiosis

SMC1β (C-16) - sc-27961 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

p-SMC1 (5911G5) - sc-56746 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

Western blot analysis of SMC1 expression in lambda protein phosphatase treated (A,C) or untreated (B,D) HeLa nuclear extract. Antibodies tested include p-SMC1 (5911G5): sc-56746 (A,B) and SMC1 (P-17): sc-21078 (C,D).

p-SMC1 (5H24) - sc-71789 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

p-SMC1 (4H374) - sc-71790 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

Anti-SMC1 (phospho S360) antibody [EPR4498(2)] - ab133452 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR4498(2)

All lanes : Anti-SMC1 (phospho S360) antibody [EPR4498(2)] (ab133452) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : HeLa cell lysate treated with Alkaline PhosphataseLysates/proteins at 10 µg per lane.SecondaryHRP labelled Goat anti Rabbit IgG at 1/2000 dilution

Anti-SMC1 (phospho S957) antibody - ab47414 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue in the presence (right) and absence (left) of synthetic phosphopeptide, using ab47413 at 1/50 dilution.

Anti-SMC1 (phospho S957) antibody [EP2857Y] - ab137871 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP2857Y

All lanes : Anti-SMC1 (phospho S957) antibody [EP2857Y] (ab137871) at 1/1000 dilutionLane 1 : HeLa cell lysate, untreatedLane 2 : HeLa cell lysate, treated with UVLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-SMC1 (phospho S957) antibody [EPR2857Y] - ab75768 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR2857Y

All lanes : Anti-SMC1 (phospho S957) antibody [EPR2857Y] (ab75768) at 1/1000 dilutionLane 1 : Hela cells lysate, untreatedLane 2 : Hela cells lysate, treated with APLysates/proteins at 10 µg per lane.SecondaryHRP-conjugated goat anti-rabbit at 1/2000 dilution

Anti-SMC1 (phospho S966) antibody - ab1276 from Abcam

Prices	$401.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence analysis of neocarzinostatin treated asynchronous HeLa cells labelling SMC1 (phospho S966) with ab1276 at 1/5000 (0.2µg/ml). A DyLight® 594-conjugated anti-rabbit IgG (1/100) was used as the secondary antibody.

Anti-SMC1 (phospho S966) antibody - ab73994 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-SMC1 (phospho S966) antibody (ab73994) at 1/500 dilutionLane 1 : extracts from HUVEC cells treated with etoposide (24uM, 24hours),Lane 2 : extracts from HUVEC cells, treated with etoposide (24uM, 24hours), with immunising phosphopeptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-SMC1 (phospho S966) antibody [EP2858Y] - ab81306 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP2858Y

All lanes : Anti-SMC1 (phospho S966) antibody [EP2858Y] (ab81306) at 1/1000 dilutionLane 1 : HeLa cell lysates un-treatedLane 2 : HeLa cell lysates treated with hydroxyureaLysates/proteins at 10 µg per lane.SecondaryHRP goat anti-rabbit at 1/2000 dilution

Anti-SMC1 (phospho S966) antibody [EPFHCR37D] - ab133464 from Abcam

Prices	$313.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPFHCR37D

All lanes : Anti-SMC1 (phospho S966) antibody [EPFHCR37D] (ab133464) at 1/1000 dilutionLane 1 : HeLa cell lysates Lane 2 : HeLa cell lysates treated with Lambda PhosphataseLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit at 1/2000 dilution

Anti-SMC1 antibody - ab21583 from Abcam

Prices	$398.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-SMC1 antibody (ab21583) at 1 µg/mlLane 1 : 20ug HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899) at 20 µgLane 3 : 20ug HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate with Human SMC1 peptide (ab23863) at 1 µg/mlLane 4 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate (ab7899) at 20 µg with Human SMC1 peptide (ab23863) at 1 µg/mlSecondaryGoat polyclonal to Rabbit IgG (Alexa Fluor® 680) (ab28446) at 1/10000 dilution Performed under reducing conditions.

Anti-SMC1 antibody - ab56463 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

SMC1 antibody (ab56463) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human salivary gland.

Anti-SMC1 antibody - ab47415 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue in the presence (right) and absence (left) of synthetic peptide, using ab47415 at 1/50 dilution.

Anti-SMC1 antibody [C2M] - ab16147 from Abcam

Prices	$376.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal
Clone	C2M

All lanes : Anti-SMC1 antibody [C2M] (ab16147) at 1/1000 dilutionLane 1 : Human BT-20 (breast cancer cell line) - whole cell lysateLane 2 : Human BT-474 (breast cancer cell line) - whole cell lysateLane 3 : Human HBL-100 (breast cancer cell line) - whole cell lysateLane 4 : Human HCC-1937 (breast cancer cell line) - whole cell lysateLane 5 : Human HME-1 (breast cancer cell line) - whole cell lysateLane 6 : Human Hs-578T (breast cancer cell line) - whole cell lysateLane 7 : Human MCF-10A (breast cancer cell line) - whole cell lysateLane 8 : Human MDA-MB 157(breast cancer cell line) - whole cell lysateLane 9 : Human MDA-MB 231 (breast cancer cell line) - whole cell lysateLane 10 : Human MDA-MB 436(breast cancer cell line) - whole cell lysateLane 11 : Human MDA-MB 453 (breast cancer cell line) - whole cell lysateLane 12 : Human MDA-MB 549 (breast cancer cell line) - whole cell lysateLane 13 : Human T47D (breast cancer cell line) - whole cell lysateLysates/proteins at 50 µg per lane.Second

Anti-SMC1 antibody [EP2879Y] - ab75819 from Abcam

Prices	$379.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EP2879Y

ab75819 at 1/100 dilution staining SMC1 in HeLa cells by Immunofluorescence.

Anti-SMC1 antibody [EPR2879(2)] - ab109238 from Abcam

Prices	$385.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR2879(2)

All lanes : Anti-SMC1 antibody [EPR2879(2)] (ab109238) at 1/10000 dilutionLane 1 : 293T cell lysateLane 2 : HeLa cell lysateLane 3 : Jurkat cell lysateLysates/proteins at 10 µg per lane.

Anti-SMC1L2 antibody - ab96206 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SMC1L2 antibody (ab96206) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-SMC1L2 antibody - ab116373 from Abcam

Prices	$370.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SMC1L2 antibody (ab116373) at 1/100 dilution + Human normal uterus cell line lysate at 35 µg

Anti-SMC1L2 antibody - ab57086 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab57086 SMC1L2 antibody at 1ug/ml.

Anti-SMC1B Antibody (aa154-433) - LS-C186237 from LifeSpan Bioscience

Prices	$335.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded SAS xenograft using SMC1B antibody at 1:500 dilution.

Anti-SMC1B Antibody (aa737-765, AP) - LS-C269678 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SMC1B Antibody (aa737-765, Biotin) - LS-C269681 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SMC1B Antibody (aa737-765, APC) - LS-C269680 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

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