UIMC1

Gene Symbol	UIMC1
Entrez Gene	51720
Alt Symbol	RAP80, X2HRIP110
Species	Human
Gene Type	protein-coding
Description	ubiquitin interaction motif containing 1
Other Description	BRCA1-A complex subunit RAP80|receptor associated protein 80|receptor-associated protein 80|retinoid X receptor-interacting protein 110|retinoid x receptor interacting protein|ubiquitin interaction motif-containing protein 1
Swissprots	Q9BZR1 Q5XKQ1 B3KMZ1 Q9BZR5 B4E3N2 Q9UHX7 Q8N5B9 A8MSA1 Q96RL1 Q7Z3W7
Accessions	CAK32264 CAK32265 EAW85041 EAW85042 EAW85043 EAW85044 EAW85045 EAW85046 Q96RL1 AF113538 AAF14875 AF284749 AAG59851 AF284753 AAG59855 AF349313 AAK61871 AK023044 BAG51153 AK304794 BAG65544 AL137375 CAB70716 BC006078 AAH06078 BC032561 AAH32561 BP270983 BX537376 CAD97618 CF994701 EF077642 EF077643 EF077644 EU831931 ACE87372 EU832026 ACE86688 JF432220 ADZ15437 XM_005265930 XP_005265987 XM_005265931 XP_005265988 XM_005265932 XP_005265989 XM_005265933 XP_005265990 XM_005265934 XP_005265991 XM_005265935 XP_005265992 XM_005265936 XP_005265993 XM_006714871 XP_006714934 XM_006714872 XP_006714935 XM_006714873 XP_006714936 XM_006714874 XP_006714937 XM_011534568 XP_011532870 XM_011534569 XP_011532871 XM_011534570 XP_011532872 XR_941103 NM_001199297 NP_001186226 NM_001199298 NP_001186227 NM_016290 NP_057374
Function	Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMe
Subcellular Location	Nucleus {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue Specificity	Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis. {ECO:0000269|PubMed:12080054}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® RAP80 siRNA I - 14519 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

RAP80 CRISPR/Cas9 KO Plasmid (h) - sc-408232 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RAP80 HDR Plasmid (h) - sc-408232-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RAP80 Double Nickase Plasmid (h) - sc-408232-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RAP80 Double Nickase Plasmid (h2) - sc-408232-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RAP80 CRISPR Activation Plasmid (h) - sc-408232-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RAP80 CRISPR Activation Plasmid (h2) - sc-408232-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

RAP80 Lentiviral Activation Particles (h) - sc-408232-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RAP80 Lentiviral Activation Particles (h2) - sc-408232-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

RAP80 siRNA (h) - sc-92007 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RAP80 shRNA Plasmid (h) - sc-92007-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RAP80 shRNA (h) Lentiviral Particles - sc-92007-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU157801 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22482 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22482 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR02381 from Sigma-Aldrich Category miRNA

UIMC1 siRNA (Human) - CRH9917 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

UIMC1 - MBS8237360 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human UIMC1 (NM_016290.4) - SHH440344 from Creative biogene Category siRNA Species Reactivities Human

UIMC1 shRNA Plasmid (Human) - CHH9917 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

UIMC1 miRNA 3'UTR clone - MiUTR3H-10605 from Creative biogene Species Reactivities Human

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