UIMC1

Gene Symbol	UIMC1
Entrez Gene	51720
Alt Symbol	RAP80, X2HRIP110
Species	Human
Gene Type	protein-coding
Description	ubiquitin interaction motif containing 1
Other Description	BRCA1-A complex subunit RAP80|receptor associated protein 80|receptor-associated protein 80|retinoid X receptor-interacting protein 110|retinoid x receptor interacting protein|ubiquitin interaction motif-containing protein 1
Swissprots	Q9BZR1 Q5XKQ1 B3KMZ1 Q9BZR5 B4E3N2 Q9UHX7 Q8N5B9 A8MSA1 Q96RL1 Q7Z3W7
Accessions	CAK32264 CAK32265 EAW85041 EAW85042 EAW85043 EAW85044 EAW85045 EAW85046 Q96RL1 AF113538 AAF14875 AF284749 AAG59851 AF284753 AAG59855 AF349313 AAK61871 AK023044 BAG51153 AK304794 BAG65544 AL137375 CAB70716 BC006078 AAH06078 BC032561 AAH32561 BP270983 BX537376 CAD97618 CF994701 EF077642 EF077643 EF077644 EU831931 ACE87372 EU832026 ACE86688 JF432220 ADZ15437 XM_005265930 XP_005265987 XM_005265931 XP_005265988 XM_005265932 XP_005265989 XM_005265933 XP_005265990 XM_005265934 XP_005265991 XM_005265935 XP_005265992 XM_005265936 XP_005265993 XM_006714871 XP_006714934 XM_006714872 XP_006714935 XM_006714873 XP_006714936 XM_006714874 XP_006714937 XM_011534568 XP_011532870 XM_011534569 XP_011532871 XM_011534570 XP_011532872 XR_941103 NM_001199297 NP_001186226 NM_001199298 NP_001186227 NM_016290 NP_057374
Function	Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMe
Subcellular Location	Nucleus {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue Specificity	Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis. {ECO:0000269|PubMed:12080054}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human RAP80 protein fragment - ab189671 from Abcam Category Protein Prices $519.00 Sizes 250 µg Source E. coli Species Human

Human RAP80 full length protein - ab162648 from Abcam Category Protein Source Wheat germ Species Human

Human RAP80 protein fragment - ab189682 from Abcam Category Protein Source E. coli Species Human

UIMC1 / RAP80 Antibody Blocking Peptide - LS-E27141 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UIMC1 / RAP80 Antibody Blocking Peptide - LS-E30387 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

UIMC1 / RAP80 Antibody Blocking Peptide - LS-E30388 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RAP80 Recombinant Protein - H00051720-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

RAP80 Blocking Peptide - NBP1-76829PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RAP80 Blocking Peptide - NBP1-76828PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RAP80 blocking peptide - GTX88338-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat

Recombinant Human RAP80 UIM Domains Agarose, CF - AM-120-250 from R&D Systems Category Protein

Recombinant Human RAP80 UIM Domains Biotin, CF - UBE-235-250 from R&D Systems Category Protein

Recombinant Human His6-RAP80 UIM Domains, CF - UBE-230-250 from R&D Systems Category Protein

RAP80 Peptide - AC21-1960-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

UIMC1 / RAP80 - H00051720-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UIMC1 / RAP80 - H00051720-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UIMC1 / RAP80 Control Peptide - AP30706CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

UIMC1 / RAP80 Control Peptide - AP30707CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

RAP80 Peptide - 4327P from ProSci Category Peptide Species Human

RAP80 Peptide - 4325P from ProSci Category Peptide Species Human

UIMC1 fusion protein - ag4582 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

UIMC1 fusion protein - ag14475 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human BRCA1-A complex subunit RAP80(UIMC1) - CSB-YP857019HU CSB-EP857019HU CSB-BP857019HU CSB-MP857019HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human RAP80 UIM Domains Agarose Protein, CF - AM-120 from R&D Systems Category Protein Prices $215.00 Sizes 250 µl Species Human

Recombinant Human RAP80 UIM Domains Biotin Protein, CF - UBE-235 from R&D Systems Category Protein Prices $245.00 Sizes 250 µg Species Human

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