UIMC1

Gene Symbol UIMC1
Entrez Gene 51720
Alt Symbol RAP80, X2HRIP110
Species Human
Gene Type protein-coding
Description ubiquitin interaction motif containing 1
Other Description BRCA1-A complex subunit RAP80|receptor associated protein 80|receptor-associated protein 80|retinoid X receptor-interacting protein 110|retinoid x receptor interacting protein|ubiquitin interaction motif-containing protein 1
Swissprots Q9BZR1 Q5XKQ1 B3KMZ1 Q9BZR5 B4E3N2 Q9UHX7 Q8N5B9 A8MSA1 Q96RL1 Q7Z3W7
Accessions CAK32264 CAK32265 EAW85041 EAW85042 EAW85043 EAW85044 EAW85045 EAW85046 Q96RL1 AF113538 AAF14875 AF284749 AAG59851 AF284753 AAG59855 AF349313 AAK61871 AK023044 BAG51153 AK304794 BAG65544 AL137375 CAB70716 BC006078 AAH06078 BC032561 AAH32561 BP270983 BX537376 CAD97618 CF994701 EF077642 EF077643 EF077644 EU831931 ACE87372 EU832026 ACE86688 JF432220 ADZ15437 XM_005265930 XP_005265987 XM_005265931 XP_005265988 XM_005265932 XP_005265989 XM_005265933 XP_005265990 XM_005265934 XP_005265991 XM_005265935 XP_005265992 XM_005265936 XP_005265993 XM_006714871 XP_006714934 XM_006714872 XP_006714935 XM_006714873 XP_006714936 XM_006714874 XP_006714937 XM_011534568 XP_011532870 XM_011534569 XP_011532871 XM_011534570 XP_011532872 XR_941103 NM_001199297 NP_001186226 NM_001199298 NP_001186227 NM_016290 NP_057374
Function Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1. {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMe
Subcellular Location Nucleus {ECO:0000269|PubMed:12080054, ECO:0000269|PubMed:17525340, ECO:0000269|PubMed:17525341, ECO:0000269|PubMed:17525342, ECO:0000269|PubMed:17621610, ECO:0000269|PubMed:17643121}. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs).
Tissue Specificity Expressed in testis, ovary, thymus and heart. Expressed in germ cells of the testis. {ECO:0000269|PubMed:12080054}.

RAP80 (D1T6Q) Rabbit mAb - 14466 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D1T6Q
Western blot analysis of extracts from 293T cells, transfected with 100 nM SignalSilence ® Control siRNA (Unconjugated) #6568 (-) or SignalSilence ® RAP80 siRNA #14519 (+), using RAP80 (D1T6Q) Rabbit mAb (upper) and α-Actinin (D6F6) XP ® Rabbit mAb #6487 (lower).

RAP80 (C-13) - sc-107986 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RAP80 (C-13): sc-107986. Western blot analysis of RAP80 expression in Hs 181 Tes whole cell lysate.

RAP80 (H-260) - sc-98339 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

RAP80 (P-16) - sc-107989 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RAP80 (S-15) - sc-107991 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-RAP80 antibody - ab70822 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RAP80 antibody (ab70822) at 1 µg/mlLane 1 : HeLa whole cell lysate at 15 µgLane 2 : HeLa whole cell lysate at 5 µgLane 3 : 293T whole cell lysate at 50 µg

Anti-RAP80 antibody - ab114855 from Abcam

Prices $428.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab114855, at 1/250 dilution, staining RAP80 in formalin-fixed, paraffin-embedded Human ovarian carcinoma tissue by Immunohistochemistry with DAB staining.

Anti-RAP80 antibody - ab67606 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-RAP80 antibody (ab67606) at 1/500 dilutionLane 1 : RAP80 transfected 293T cell lysate with the recombinant fragment used as the immunogenLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP conjugated at 1/2500 dilution

Anti-RAP80 antibody [EPR5315] - ab124763 from Abcam

Prices $313.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5315
All lanes : Anti-RAP80 antibody [EPR5315] (ab124763) at 1/10000 dilutionLane 1 : HeLa cell lysateLane 2 : Human ovary cancer lysateLane 3 : 293T cell lysateLane 4 : HT-1080 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-Rabbit HRP at 1/2000 dilution

Anti-RAP80 antibody - C-terminal - ab192215 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RAP80 antibody - C-terminal (ab192215) at 1/1000 dilution + HT1080 cell line lysate at 35 µgSecondarygoat anti-rabbit IgG H&L(HRP) at 1/5000 dilution

Anti-UIMC1 / RAP80 Antibody (C-Terminus) - LS-C93646 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-UIMC1 / RAP80 Antibody (aa600-650) - LS-C287624 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UIMC1 / RAP80 Antibody (Internal) - LS-C345854 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of UIMC1 Antibody with human HepG2 Whole Cell lysate.

Anti-UIMC1 / RAP80 Antibody (Internal) - LS-C345853 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of UIMC1 Antibody with human MCF7 Whole Cell lysate.

Anti-UIMC1 / RAP80 Antibody (C-Terminus) - LS-C287625 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human RAP80 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-RAP80 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-UIMC1 / RAP80 Antibody (Internal, clone EPR5315) - LS-C138510 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5315
IHC of paraffin-embedded human testis tissue using anti-RAP80 antibody.

Anti-UIMC1 / RAP80 Antibody - LS-C346307 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of U20S cell using UIMC1 antibody. Blue: DAPI for nuclear staining.

Anti-UIMC1 / RAP80 Antibody (C-Terminus) - LS-C285965 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human RAP80 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-RAP80 used at a dilution of 1:100. Detection: Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Antibody used at a dilution of 1:100.

Anti-UIMC1 / RAP80 Antibody (aa535-548) IHC-plus™ - LS-B7372 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-UIMC1 / RAP80 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B7372 concentration 3.75 ug/ml.

Anti-UIMC1 / RAP80 Antibody (aa567-601) - LS-C344242 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of lysate from HT-1080 cell line with UIMC1 Antibody. Antibody was diluted at 1:1000. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35 ug.

Anti-UIMC1 / RAP80 Antibody (C-Terminus) IHC-plus™ - LS-B2706 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-UIMC1 / RAP80 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2706 concentration 5 ug/ml.

Anti-UIMC1 / RAP80 Antibody (N-Terminus) IHC-plus™ - LS-B2707 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-UIMC1 / RAP80 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B2707 concentration 5 ug/ml.

RAP80 Antibody - NBP1-87156 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RAP80 Antibody [NBP1-87156] - Analysis in human cell line HDLM-2.

RAP80 Antibody - NBP1-76829 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: RAP80 Antibody [NBP1-76829] - 293 cell lysate in (A) the absence and (B) presence of blocking peptide with RAP80 antibody at 1 ug/ml.

RAP80 Antibody - NB100-2347 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RAP80 Antibody [NB100-2347] - Detection of Human RAP80 on HeLa whole cell lysate. RAP80 was also immunoprecipitated using rabbit anti-RAP80 antibody NB100-2346.
Search more