| Gene Symbol | Exosc9 |
|---|---|
| Entrez Gene | 294975 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | exosome component 9 |
| Other Description | exosome complex component RRP45|exosome complex exonuclease RRP45 |
| Swissprots | Q4QR75 |
| Accessions | EDM01279 EDM01280 EDM01281 Q4QR75 BC097413 AAH97413 XM_008760913 XP_008759135 NM_001025406 NP_001020577 |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q06265}. Nucleus {ECO:0000250|UniProtKB:Q06265}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q06265}. Note=Colocalizes with SETX in nuclear foci upon induction of transcription-related DNA damage at the S phase (By similarity). {ECO:0000250|UniProtKB:Q06265}. |
| Top Pathways | RNA degradation |
Rat Exosc9 cDAN Clone(NM_001025406.1) - CDFR003959 from Creative Biomart
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Rat EXOSC9 ORF clone(NM_001025406.1) - CDCG000928 from Creative Biomart
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Rat Exosc9 ORF Clone(NM_001025406.1) - CDCR370934 from Creative Biomart
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Rat Exosc9 ORF Clone(NM_001025406.1) - CDCR370934 from Creative biogene
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Rat Exosc9 cDNA Clone(NM_001025406.1) - CDFR003959 from Creative biogene
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