| Gene Symbol | Exosc9 |
|---|---|
| Entrez Gene | 294975 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | exosome component 9 |
| Other Description | exosome complex component RRP45|exosome complex exonuclease RRP45 |
| Swissprots | Q4QR75 |
| Accessions | EDM01279 EDM01280 EDM01281 Q4QR75 BC097413 AAH97413 XM_008760913 XP_008759135 NM_001025406 NP_001020577 |
| Function | Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways |
| Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q06265}. Nucleus {ECO:0000250|UniProtKB:Q06265}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q06265}. Note=Colocalizes with SETX in nuclear foci upon induction of transcription-related DNA damage at the S phase (By similarity). {ECO:0000250|UniProtKB:Q06265}. |
| Top Pathways | RNA degradation |
CompoZr® Knockout ZFN Kit - CKOZFN53650 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND53650 from Sigma-Aldrich
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EXOSC9 siRNA (Rat) - CRR4384 from Cohesion Biosciences
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EXOSC9 - MBS8221038 from MyBioSource
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shRNA set against Rat EXOSC9 (NM_001025406.1) - SHH288185 from Creative biogene
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shRNA set against Rat Exosc9(NM_001025406.1) - SHH042311 from Creative biogene
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Rat EXOSC9 siRNA - orb299233 from Biorbyt
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EXOSC9 shRNA Plasmid (Rat) - CHR4384 from Cohesion Biosciences
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EXOSC9 miRNA 3'UTR clone - MiUTR1R-01789 from Creative biogene
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