Exosc9

Gene Symbol Exosc9
Entrez Gene 294975
Alt Symbol -
Species Rat
Gene Type protein-coding
Description exosome component 9
Other Description exosome complex component RRP45|exosome complex exonuclease RRP45
Swissprots Q4QR75
Accessions EDM01279 EDM01280 EDM01281 Q4QR75 BC097413 AAH97413 XM_008760913 XP_008759135 NM_001025406 NP_001020577
Function Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways
Subcellular Location Cytoplasm {ECO:0000250}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q06265}. Nucleus {ECO:0000250|UniProtKB:Q06265}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q06265}. Note=Colocalizes with SETX in nuclear foci upon induction of transcription-related DNA damage at the S phase (By similarity). {ECO:0000250|UniProtKB:Q06265}.
Top Pathways RNA degradation

Recombinant Rat Exosome complex component RRP45(Exosc9) - CSB-YP689926RA CSB-EP689926RA CSB-BP689926RA CSB-MP689926RA from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Rat

Recombinant Rat EXOSC9 Protein - EXOSC9-2172R from Creative Biomart

Category Protein
Source Mammalian Cells
Species Rat

Exosome complex component RRP45 (Exosc9), Recombinant Protein - MBS1328613 from MyBioSource

Category Protein
Prices $1,215.00, $1,215.00, $1,435.00, $1,435.00, $1,965.00, $1,965.00, $2,430.00, $2,430.00
Sizes 50 µg (Baculovirus), 500 µg (E-Coli), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Rat
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