Gene Symbol | CYP2U1 |
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Entrez Gene | 113612 |
Alt Symbol | P450TEC, SPG49, SPG56 |
Species | Human |
Gene Type | protein-coding |
Description | cytochrome P450, family 2, subfamily U, polypeptide 1 |
Other Description | cytochrome P450 2U1|spastic paraplegia 49 |
Swissprots | B2RMV7 Q96EQ6 Q7Z449 |
Accessions | EAX06215 EAX06216 EAX06217 Q7Z449 AK026498 AK290002 BAF82691 AK298989 BAG61081 AK303284 BAG64362 AK304724 BAG65487 AY343323 AAQ21380 BC012027 AAH12027 BC132767 AAI32768 BC136483 AAI36484 BC144148 BU838483 BX354124 BX437421 CD672608 HQ258621 ADR83373 XM_005262717 XP_005262774 XM_005262720 XP_005262777 NM_183075 NP_898898 |
Function | Catalyzes the hydroxylation of arachidonic acid, docosahexaenoic acid and other long chain fatty acids. May modulate the arachidonic acid signaling pathway and play a role in other fatty acid signaling processes. {ECO:0000269|PubMed:14660610}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:14660610}; Multi-pass membrane protein {ECO:0000269|PubMed:14660610}. Microsome membrane {ECO:0000269|PubMed:14660610}. |
Tissue Specificity | Widely expressed with stronger expression in thymus, heart and cerebellum. {ECO:0000269|PubMed:14660610, ECO:0000269|PubMed:14975754, ECO:0000269|PubMed:15752708}. |
Top Pathways | Arachidonic acid metabolism |
CYP2U1 CRISPR/Cas9 KO Plasmid (h) - sc-408596 from Santa Cruz Biotechnology
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CYP2U1 HDR Plasmid (h) - sc-408596-HDR from Santa Cruz Biotechnology
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CYP2U1 Double Nickase Plasmid (h) - sc-408596-NIC from Santa Cruz Biotechnology
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CYP2U1 Double Nickase Plasmid (h2) - sc-408596-NIC-2 from Santa Cruz Biotechnology
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CYP2U1 CRISPR Activation Plasmid (h) - sc-408596-ACT from Santa Cruz Biotechnology
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CYP2U1 CRISPR Activation Plasmid (h2) - sc-408596-ACT-2 from Santa Cruz Biotechnology
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CYP2U1 Lentiviral Activation Particles (h) - sc-408596-LAC from Santa Cruz Biotechnology
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CYP2U1 Lentiviral Activation Particles (h2) - sc-408596-LAC-2 from Santa Cruz Biotechnology
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CYP2U1 siRNA (h) - sc-60485 from Santa Cruz Biotechnology
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CYP2U1 shRNA Plasmid (h) - sc-60485-SH from Santa Cruz Biotechnology
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CYP2U1 shRNA (h) Lentiviral Particles - sc-60485-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN2569 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2569 from Sigma-Aldrich
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CYP2U1 siRNA (Human) - CRJ4332 from Cohesion Biosciences
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CYP2U1 - MBS8200081 from MyBioSource
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shRNA set against Human CYP2U1 (NM_183075.2) - SHH273409 from Creative biogene
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shRNA set against Human CYP2U1(NM_183075.2) - SHG217351 from Creative biogene
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Human CYP2U1 siRNA - orb274833 from Biorbyt
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CYP2U1 shRNA Plasmid (Human) - CHJ4332 from Cohesion Biosciences
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CYP2U1 miRNA 3'UTR clone - MiUTR1H-02628 from Creative biogene
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