Gene Symbol | RASA1 |
---|---|
Entrez Gene | 5921 |
Alt Symbol | CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP |
Species | Human |
Gene Type | protein-coding |
Description | RAS p21 protein activator (GTPase activating protein) 1 |
Other Description | ras GTPase-activating protein 1|triphosphatase-activating protein |
Swissprots | Q9UDI1 B4DTL2 Q68CU6 P20936 B2R6W3 |
Accessions | EAW95931 EAW95932 EAW95933 P20936 AB209106 BAD92343 AK300263 BAG62024 AK300269 BAG62030 AK300406 BAG62136 AK312739 BAG35610 BC020761 AAH20761 BC033015 AAH33015 BC054891 AAH54891 BC070063 BC107870 BC131816 AAI31817 CF528258 CR749722 CAH18488 DA863496 M23379 AAA52517 M23612 AAA35865 XM_011543525 XP_011541827 XM_011543526 XP_011541828 XM_011543527 XP_011541829 NM_002890 NP_002881 NM_022650 NP_072179 |
Function | Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1. {ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:8360177}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:8360177}. |
Tissue Specificity | In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level). {ECO:0000269|PubMed:8360177}. |
Top Pathways | Axon guidance, MAPK signaling pathway |
Ras GAP CRISPR/Cas9 KO Plasmid (h) - sc-401376 from Santa Cruz Biotechnology
|
||||||||
Ras GAP HDR Plasmid (h) - sc-401376-HDR from Santa Cruz Biotechnology
|
||||||||
Ras GAP Double Nickase Plasmid (h) - sc-401376-NIC from Santa Cruz Biotechnology
|
||||||||
Ras GAP Double Nickase Plasmid (h2) - sc-401376-NIC-2 from Santa Cruz Biotechnology
|
||||||||
Ras GAP CRISPR Activation Plasmid (h) - sc-401376-ACT from Santa Cruz Biotechnology
|
||||||||
Ras GAP CRISPR Activation Plasmid (h2) - sc-401376-ACT-2 from Santa Cruz Biotechnology
|
||||||||
Ras GAP Lentiviral Activation Particles (h) - sc-401376-LAC from Santa Cruz Biotechnology
|
||||||||
Ras GAP Lentiviral Activation Particles (h2) - sc-401376-LAC-2 from Santa Cruz Biotechnology
|
||||||||
Ras GAP siRNA (h) - sc-29467 from Santa Cruz Biotechnology
|
||||||||
Ras GAP shRNA Plasmid (h) - sc-29467-SH from Santa Cruz Biotechnology
|
||||||||
Ras GAP shRNA (h) Lentiviral Particles - sc-29467-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU025771 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN17968 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17968 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR08023 from Sigma-Aldrich
|
||||||||
RASA1 siRNA (Human) - CRH4007 from Cohesion Biosciences
|
||||||||
RASA1 - MBS8204459 from MyBioSource
|
||||||||
shRNA set against Human RASA1 (NM_002890.2) - SHH389848 from Creative biogene
|
||||||||
RASA1 shRNA Plasmid (Human) - CHH4007 from Cohesion Biosciences
|
||||||||
RASA1 miRNA 3'UTR clone - MiUTR3H-00957 from Creative biogene
|
||||||||
RASA1 miRNA 3'UTR clone - MiUTR3H-00958 from Creative biogene
|