Gene Symbol | RASA1 |
---|---|
Entrez Gene | 5921 |
Alt Symbol | CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP |
Species | Human |
Gene Type | protein-coding |
Description | RAS p21 protein activator (GTPase activating protein) 1 |
Other Description | ras GTPase-activating protein 1|triphosphatase-activating protein |
Swissprots | Q9UDI1 B4DTL2 Q68CU6 P20936 B2R6W3 |
Accessions | EAW95931 EAW95932 EAW95933 P20936 AB209106 BAD92343 AK300263 BAG62024 AK300269 BAG62030 AK300406 BAG62136 AK312739 BAG35610 BC020761 AAH20761 BC033015 AAH33015 BC054891 AAH54891 BC070063 BC107870 BC131816 AAI31817 CF528258 CR749722 CAH18488 DA863496 M23379 AAA52517 M23612 AAA35865 XM_011543525 XP_011541827 XM_011543526 XP_011541828 XM_011543527 XP_011541829 NM_002890 NP_002881 NM_022650 NP_072179 |
Function | Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21; this stimulation may be further increased in the presence of NCK1. {ECO:0000269|PubMed:11389730, ECO:0000269|PubMed:8360177}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:8360177}. |
Tissue Specificity | In placental villi, detected only in the trophoblast layer (cytotrophoblast and syncytiotrophoblast). Not detected in stromal, endothelial or Hofbauer cells (at protein level). {ECO:0000269|PubMed:8360177}. |
Top Pathways | Axon guidance, MAPK signaling pathway |
Ras GAP (171) - sc-425 from Santa Cruz Biotechnology
|
||||||||||
Ras GAP (B4F8) - sc-63 from Santa Cruz Biotechnology
|
||||||||||
Ras GAP (D-18) - sc-32047 from Santa Cruz Biotechnology
|
||||||||||
Ras GAP (D-6) - sc-271436 from Santa Cruz Biotechnology
|
||||||||||
Ras GAP (P-16) - sc-32049 from Santa Cruz Biotechnology
|
||||||||||
p-Ras GAP (pY460.19A) - sc-136481 from Santa Cruz Biotechnology
|
||||||||||
Anti-RASA1 (phospho Y460) antibody [EPR2620(2)] - ab109465 from Abcam
|
||||||||||
Anti-RASA1 antibody - ab40807 from Abcam
|
||||||||||
Anti-RASA1 antibody - ab18841 from Abcam
|
||||||||||
Anti-RASA1 antibody - ab55663 from Abcam
|
||||||||||
Anti-RASA1 antibody [1H2] - ab139301 from Abcam
|
||||||||||
Anti-RASA1 antibody [B4F8] - ab2922 from Abcam
|
||||||||||
Anti-RASA1 antibody [EP536Y] - ab40677 from Abcam
|
||||||||||
Anti-RASA1 antibody - C-terminal - ab171432 from Abcam
|
||||||||||
Anti-RASA1 Antibody (aa132-350) - LS-C38754 from LifeSpan Bioscience
|
||||||||||
Anti-RASA1 / RASGAP Antibody (C-Terminus) - LS-C38757 from LifeSpan Bioscience
|
||||||||||
Anti-RASA1 / RASGAP Antibody - LS-C38758 from LifeSpan Bioscience
|
||||||||||
Anti-RASA1 Antibody - LS-C38759 from LifeSpan Bioscience
|
||||||||||
Anti-RASA1 Antibody (aa171-448) - LS-C38760 from LifeSpan Bioscience
|
||||||||||
Anti-RASA1 Antibody (aa1034-1047) - LS-C38761 from LifeSpan Bioscience
|
||||||||||
Anti-RASA1 Antibody (aa158-455) - LS-C38762 from LifeSpan Bioscience
|
||||||||||
Anti-RASA1 Antibody (clone 2C12) - LS-C133082 from LifeSpan Bioscience
|
||||||||||
Anti-RASA1 Antibody (aa953-1002) - LS-C135002 from LifeSpan Bioscience
|
||||||||||
Anti-RASA1 Antibody - LS-C48306 from LifeSpan Bioscience
|
||||||||||
Anti-RASA1 Antibody (aa966-993, AP) - LS-C239752 from LifeSpan Bioscience
|