| Gene Symbol |
EIF5AL1
|
| Entrez Gene |
143244
|
| Alt Symbol |
EIF5AP1, bA342M3.3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 5A-like 1
|
| Other Description |
eukaryotic translation initiation factor 5A pseudogene 1|eukaryotic translation initiation factor 5A-1-like
|
| Swissprots |
Q6IS14
|
| Accessions |
AAD14095 Q6IS14 BC070048 AAH70048 NM_001099692 NP_001093162
|
| Function |
mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250}.
|