Gene Symbol | EIF5AL1 |
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Entrez Gene | 143244 |
Alt Symbol | EIF5AP1, bA342M3.3 |
Species | Human |
Gene Type | protein-coding |
Description | eukaryotic translation initiation factor 5A-like 1 |
Other Description | eukaryotic translation initiation factor 5A pseudogene 1|eukaryotic translation initiation factor 5A-1-like |
Swissprots | Q6IS14 |
Accessions | AAD14095 Q6IS14 BC070048 AAH70048 NM_001099692 NP_001093162 |
Function | mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. Mediates effects of polyamines on neuronal process extension and survival. May play an important role in brain development and function, and in skeletal muscle stem cell differentiation (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Nucleus, nuclear pore complex {ECO:0000250}. Note=Hypusine modification promotes the nuclear export and cytoplasmic localization and there was a dynamic shift in the localization from predominantly cytoplasmic to primarily nuclear under apoptotic inducing conditions. {ECO:0000250}. |
eIF5AL1 CRISPR/Cas9 KO Plasmid (h) - sc-418751 from Santa Cruz Biotechnology
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eIF5AL1 HDR Plasmid (h) - sc-418751-HDR from Santa Cruz Biotechnology
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eIF5AL1 Double Nickase Plasmid (h) - sc-418751-NIC from Santa Cruz Biotechnology
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eIF5AL1 Double Nickase Plasmid (h2) - sc-418751-NIC-2 from Santa Cruz Biotechnology
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eIF5AL1 CRISPR Activation Plasmid (h) - sc-418751-ACT from Santa Cruz Biotechnology
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eIF5AL1 CRISPR Activation Plasmid (h2) - sc-418751-ACT-2 from Santa Cruz Biotechnology
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eIF5AL1 Lentiviral Activation Particles (h) - sc-418751-LAC from Santa Cruz Biotechnology
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eIF5AL1 Lentiviral Activation Particles (h2) - sc-418751-LAC-2 from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN7790 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7790 from Sigma-Aldrich
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EIF5AL1 siRNA (Human) - CRJ5366 from Cohesion Biosciences
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EIF5AL1 - MBS8203164 from MyBioSource
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shRNA set against Human EIF5AL1 (NM_001099692.1) - SHH284813 from Creative biogene
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EIF5AL1 shRNA Plasmid (Human) - CHJ5366 from Cohesion Biosciences
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EIF5AL1 miRNA 3'UTR clone - MiUTR4H-TG03039 from Creative biogene
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