MME

Gene Symbol	MME
Entrez Gene	4311
Alt Symbol	CALLA, CD10, NEP, SFE
Species	Human
Gene Type	protein-coding
Description	membrane metallo-endopeptidase
Other Description	atriopeptidase|common acute lymphocytic leukemia antigen|enkephalinase|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)|membrane metallo-endopeptidase variant 1|membrane metallo-endopeptidase variant 2|neprilysin|neprilysin-390|neprilysin-411|neutral endopeptidase 24.11|skin fibroblast elastase
Swissprots	D3DNJ9 A8K6U6 Q3MIX4 P08473
Accessions	AAA52294 ACA05913 ACA05914 CCQ42996 EAW78753 EAW78754 EAW78755 EAW78756 EAW78757 EAW78758 P08473 AK291761 BAF84450 AK310664 AL833459 BC101632 AAI01633 BC101658 AAI01659 BC106070 AAI06071 BC143465 AAI43466 BM151602 BP418894 BX647134 DA574242 DB142029 J03779 AAA51915 KC143287 AGE12493 KC143288 AGE12494 X07166 CAA30157 Y00811 CAA68752 XM_006713646 XP_006713709 XM_006713647 XP_006713710 XM_011512855 XP_011511157 XM_011512856 XP_011511158 XM_011512857 XP_011511159 XM_011512858 XP_011511160 NM_000902 NP_000893 NM_007287 NP_009218 NM_007288 NP_009219 NM_007289 NP_009220
Function	Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). {ECO:0000269|PubMed:15283675, ECO:0000269|PubMed:17101991, ECO:0000269|PubMed:20876573, ECO:0000269|PubMed:2531377, ECO:0000269|PubMed:2972276}.
Subcellular Location	Cell membrane; Single-pass type II membrane protein.
Top Pathways	Hematopoietic cell lineage, Alzheimer's disease, Protein digestion and absorption, Renin-angiotensin system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CD10 protein fragment - ab157051 from Abcam Category Protein Prices $410.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Avian Influenza A Nonstructural 2 peptide - ab51480 from Abcam Category Peptide Prices $181.00 Sizes 50 µg

CD10 peptide - ab109275 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human CD10 full length protein - ab132936 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human CD10 protein fragment - ab114211 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Human CD10 protein fragment - ab155720 from Abcam Category Protein Prices $345.00 Sizes 50 µg Source HEK 293 cells Species Human

Human CD10 protein fragment - ab195085 from Abcam Category Protein Prices $199.00 Sizes 2 µg Source HEK 293 cells Species Human

NEP / DDR1 Antibody Blocking Peptide - LS-E28750 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NEP / DDR1 Antibody Blocking Peptide - LS-E28751 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NEP / DDR1 Antibody Blocking Peptide - LS-E8839 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NEP / DDR1 Antibody Blocking Peptide - LS-E28641 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NEP / DDR1 Antibody Blocking Peptide - LS-E28642 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NEP / DDR1 Antibody Blocking Peptide - LS-E9162 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MME-Antibody-Center-Blocking-peptide - BP10192c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MME-Antibody-Center-Blocking-Peptide - BP7329c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Neprilysin-Antibody-C-term-Blocking-Peptide - BP7329b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Neprilysin (CHO-expressed), CF - 1182-ZNC-010 from R&D Systems Category Protein Source Chinese Hamster Ovary cell line, CHO-derived, Tyr52-Trp750 , with an N-terminal 6-His tag

Human Atriopeptidase protein - orb82953 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Human Species Human

Human Atriopeptidase protein - orb82952 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 10 μg, 20 μg Source Human Species Human

Human Neprilysin Protein - abx068218 from Abbexa Category Protein Source E.coli Species Human

Human Neprilysin Protein - abx068219 from Abbexa Category Protein Source E.coli Species Human

CD10 / Neprilysin - H00004311-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD10 / Neprilysin - H00004311-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD10 / Neprilysin - H00004311-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CD10 / Neprilysin - H00004311-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

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