MME

Gene Symbol MME
Entrez Gene 4311
Alt Symbol CALLA, CD10, NEP, SFE
Species Human
Gene Type protein-coding
Description membrane metallo-endopeptidase
Other Description atriopeptidase|common acute lymphocytic leukemia antigen|enkephalinase|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)|membrane metallo-endopeptidase variant 1|membrane metallo-endopeptidase variant 2|neprilysin|neprilysin-390|neprilysin-411|neutral endopeptidase 24.11|skin fibroblast elastase
Swissprots D3DNJ9 A8K6U6 Q3MIX4 P08473
Accessions AAA52294 ACA05913 ACA05914 CCQ42996 EAW78753 EAW78754 EAW78755 EAW78756 EAW78757 EAW78758 P08473 AK291761 BAF84450 AK310664 AL833459 BC101632 AAI01633 BC101658 AAI01659 BC106070 AAI06071 BC143465 AAI43466 BM151602 BP418894 BX647134 DA574242 DB142029 J03779 AAA51915 KC143287 AGE12493 KC143288 AGE12494 X07166 CAA30157 Y00811 CAA68752 XM_006713646 XP_006713709 XM_006713647 XP_006713710 XM_011512855 XP_011511157 XM_011512856 XP_011511158 XM_011512857 XP_011511159 XM_011512858 XP_011511160 NM_000902 NP_000893 NM_007287 NP_009218 NM_007288 NP_009219 NM_007289 NP_009220
Function Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). {ECO:0000269|PubMed:15283675, ECO:0000269|PubMed:17101991, ECO:0000269|PubMed:20876573, ECO:0000269|PubMed:2531377, ECO:0000269|PubMed:2972276}.
Subcellular Location Cell membrane; Single-pass type II membrane protein.
Top Pathways Hematopoietic cell lineage, Alzheimer's disease, Protein digestion and absorption, Renin-angiotensin system

CD10 (CB-CALLA) Mouse mAb - 3565 from Cell Signaling Technology

Prices $239.00
Sizes 400 µl (100 tests)
Host Mouse
Clonality Monoclonal
Clone CB-CALLA
Flow cytometric analysis of whole blood, using CD10 (CB-CALLA) Mouse mAb.

CD10 (F-4) - sc-46656 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD10 (F-4): sc-46656. Western blot analysis of CD10 expression in LNCaP (A), GA-10 (B) and JM1 (C) whole cell lysates.

CD10 (H-321) - sc-9149 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CD10 (H-321): sc-9149. Immunofluorescence staining of methanol-fixed LNCaP cells showing membrane staining.

CD10 (FR4D11) - sc-7632 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD10 (FR4D11) FITC: sc-7632 FITC. FCM analysis of GA-10 cells. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-2855.

CD10 (E-14) - sc-102424 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
CD10 (E-14): sc-102424. Immunoperoxidase staining of formalin fixed, paraffin-embedded human spleen tissue showing membrane and cytoplasmic staining of cells in white pulp and cells in red pulp.

CD10 (P-13) - sc-102426 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
CD10 (P-13): sc-102426. Western blot analysis of CD10 expression in 293T whole cell lysate.

CD10 (SN5c/L4-1A1) - sc-80544 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD10 (SN5c/L4-1A1): sc-80544. Western blot analysis of CD10 expression in non-transfected: sc-117752 (A) and human CD10 transfected: sc-111697 (B) 293T whole cell lysates.

CD10 (2A1H5E1) - sc-65990 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD10 (2A1H5E1): sc-65990. Western blot analysis of CD10 expression in Ramos (A) and GA-10 (B) whole cell lysates.

CD10 (97C5) - sc-19993 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD10 (97C5): sc-19993. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human peripheral blood lymphocytes showing membrane staining.

CD10 (CB-Calla) - sc-52455 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CD10 (CB-Calla): sc-52455. Indirect FCM analysis of human peripheral blood leukocytes stained with CD10 (CB-Calla), followed by PE-conjugated goat anti-mouse IgG: sc-3738. Black line histogram represents the isotype control, normal mouse IgG<sub>1</sub>: sc-3877.

Anti-CD10 + CD19 antibody [FR4D11/F3 + CB19] (Dual color: FITC + PE) - ab1237 from Abcam

Prices $216.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone FR4D11/F3 + CB19

Anti-CD10 antibody - ab73409 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD10 antibody (ab73409) at 1 µg/mlLane 1 : LNCaP (Human prostate adenocarcinoma cell line) Nuclear Lysate - clone FGC (ab14857)Lane 2 : Ramos (Human Burkitt's lymphoma cell line) Whole Cell Lysate Lane 3 : Raji (Human Burkitt's lymphoma cell line) Whole Cell Lysate Lane 4 : Kidney (Human) Tissue Lysate - adult normal tissue (ab30203)Lane 5 : Placenta (Human) Tissue Lysate - adult normal tissue (ab29745)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal Secondary Antibody to Rabbit IgG - H&L (HRP), pre-adsorbed at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CD10 antibody - ab82073 from Abcam

Prices $384.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
ab82073, at 1/100 dilution, staining of Formalin-fixed, paraffin-embedded Human small intestine by Immunohistochemistry

Anti-CD10 antibody - ab59443 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD10 antibody (ab59443) at 1/1000 dilutionLane 1 : Rat Kidney Tissue Lysate (1:2) at 20 µlLane 2 : Rat Kidney Tissue Lysate (1:2) at 15 µlLane 3 : Rat Kidney Tissue Lysate (1:2) at 10 µlLane 4 : Rat Kidney Tissue Lysate (1:2) at 5 µl

Anti-CD10 antibody - ab59444 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD10 antibody (ab59444) at 1/1000 dilutionLane 1 : Recombinant Human Neprilysin-1 at 0.04 µgLane 2 : Recombinant Human Neprilysin-1 at 0.02 µgLane 3 : Recombinant Human Neprilysin-1 at 0.01 µgLane 4 : Recombinant Human Neprilysin-1 at 0.005 µgLane 5 : Recombinant Human Neprilysin-2 at 0.04 µgLane 6 : Recombinant Human Neprilysin-2 at 0.02 µgLane 7 : Recombinant Human Neprilysin-2 at 0.01 µgLane 8 : Recombinant Human Neprilysin-2 at 0.005 µg

Anti-CD10 antibody - ab59445 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CD10 antibody (ab59445) at 1/1000 dilutionLane 1 : Recombinant Human Neprilysin-1 at 0.04 µgLane 2 : Recombinant Human Neprilysin-1 at 0.02 µgLane 3 : Recombinant Human Neprilysin-1 at 0.01 µgLane 4 : Recombinant Human Neprilysin-1 at 0.005 µgLane 5 : Recombinant Human Neprilysin-2 at 0.04 µgLane 6 : Recombinant Human Neprilysin-2 at 0.02 µgLane 7 : Recombinant Human Neprilysin-2 at 0.01 µgLane 8 : Recombinant Human Neprilysin-2 at 0.005 µg

Anti-CD10 antibody [0.N.70] - ab33185 from Abcam

Host Mouse
Clonality Monoclonal
Clone 0.N.70

Anti-CD10 antibody [2A1H5E1] - ab47721 from Abcam

Host Mouse
Clonality Monoclonal
Clone 2A1H5E1
Immunohistochemical analysis of paraffin-embedded human breast ductal myoepithelium showing cytoplasmic localization using ab47721 at a 1/100 dilution, with DAB staining.

Anti-CD10 antibody [56C6] - ab951 from Abcam

Prices $394.00
Sizes 250 µl
Host Mouse
Clonality Monoclonal
Clone 56C6
ab951 at 1/20 dilution staining CD10 in MDA-MB-231 human breast cancer cells grown in mouse by immunohistochemistry (formalin/PFA-fixed paraffin-embedded sections). Sections were paraformaldehyde fixed prior to blocking in 10% casein for 30 minutes at 22°C and then incubated with ab951 for 17 hours at 4°C. A rabbit polyclonal to mouse Ig, diluted 1/200 was used as the secondary antibody.See Abreview

Anti-CD10 antibody [56C6], prediluted - ab17135 from Abcam

Prices $370.00
Sizes 6 ml
Host Mouse
Clonality Monoclonal
Clone 56C6

Anti-CD10 antibody [B-E3] - ab47200 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone B-E3
A typical staining pattern with ab47200.

Anti-CD10 antibody [B-E3] - ab27383 from Abcam

Prices $378.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone B-E3
A typical staining pattern of granulocytes with ab27383.

Anti-CD10 antibody [B-E3] (Phycoerythrin) - ab27384 from Abcam

Prices $189.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone B-E3
A typical staining pattern of granulocytes with ab27384.

Anti-CD10 antibody [BS1] - ab188880 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone BS1

Anti-CD10 antibody [CB-CALLA] (PE/Cy5®) - ab95543 from Abcam

Prices $376.00
Sizes 50 tests
Host Mouse
Clonality Monoclonal
Clone CB-CALLA
Staining of normal Human peripheral blood cells with staining buffer (autofluorescence) (open histogram), or ab95543 (colord histogram). Cells in the granulocyte gate were used for analysis.
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