MME

Gene Symbol MME
Entrez Gene 4311
Alt Symbol CALLA, CD10, NEP, SFE
Species Human
Gene Type protein-coding
Description membrane metallo-endopeptidase
Other Description atriopeptidase|common acute lymphocytic leukemia antigen|enkephalinase|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase)|membrane metallo-endopeptidase (neutral endopeptidase, enkephalinase, CALLA, CD10)|membrane metallo-endopeptidase variant 1|membrane metallo-endopeptidase variant 2|neprilysin|neprilysin-390|neprilysin-411|neutral endopeptidase 24.11|skin fibroblast elastase
Swissprots D3DNJ9 A8K6U6 Q3MIX4 P08473
Accessions AAA52294 ACA05913 ACA05914 CCQ42996 EAW78753 EAW78754 EAW78755 EAW78756 EAW78757 EAW78758 P08473 AK291761 BAF84450 AK310664 AL833459 BC101632 AAI01633 BC101658 AAI01659 BC106070 AAI06071 BC143465 AAI43466 BM151602 BP418894 BX647134 DA574242 DB142029 J03779 AAA51915 KC143287 AGE12493 KC143288 AGE12494 X07166 CAA30157 Y00811 CAA68752 XM_006713646 XP_006713709 XM_006713647 XP_006713710 XM_011512855 XP_011511157 XM_011512856 XP_011511158 XM_011512857 XP_011511159 XM_011512858 XP_011511160 NM_000902 NP_000893 NM_007287 NP_009218 NM_007288 NP_009219 NM_007289 NP_009220
Function Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids (PubMed:15283675, PubMed:8168535). Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond (PubMed:17101991). Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9 (PubMed:15283675). Involved in the degradation of atrial natriuretic factor (ANF) (PubMed:2531377, PubMed:2972276). Displays UV-inducible elastase activity toward skin preelastic and elastic fibers (PubMed:20876573). {ECO:0000269|PubMed:15283675, ECO:0000269|PubMed:17101991, ECO:0000269|PubMed:20876573, ECO:0000269|PubMed:2531377, ECO:0000269|PubMed:2972276}.
Subcellular Location Cell membrane; Single-pass type II membrane protein.
Top Pathways Hematopoietic cell lineage, Alzheimer's disease, Protein digestion and absorption, Renin-angiotensin system

CD10 CRISPR/Cas9 KO Plasmid (h) - sc-400856 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD10 HDR Plasmid (h) - sc-400856-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD10 Double Nickase Plasmid (h) - sc-400856-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD10 Double Nickase Plasmid (h2) - sc-400856-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD10 CRISPR Activation Plasmid (h) - sc-400856-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD10 CRISPR Activation Plasmid (h2) - sc-400856-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD10 Lentiviral Activation Particles (h) - sc-400856-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD10 Lentiviral Activation Particles (h2) - sc-400856-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD10 siRNA (h) - sc-29959 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CD10 shRNA Plasmid (h) - sc-29959-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CD10 shRNA (h) Lentiviral Particles - sc-29959-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU024321 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU029451 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14421 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14421 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MME siRNA (Human) - CRH2924 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Neprilysin/CD10 RNAi - H00004311-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

Neprilysin/CD10 RNAi - H00004311-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CD10 CRISPR/Cas9 KO Plasmid (h2) - sc-400856-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

CD10 HDR Plasmid (h2) - sc-400856-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human MME (NM_000902.3) - SHH342808 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human MME(NM_000902.3) - SHH193151 from Creative biogene

Category siRNA
Species Reactivities Human

MME shRNA Plasmid (Human) - CHH2924 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MME miRNA 3'UTR clone - MiUTR1H-06345 from Creative biogene

Species Reactivities Human
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