| Gene Symbol |
P4HA3
|
| Entrez Gene |
283208
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
prolyl 4-hydroxylase, alpha polypeptide III
|
| Other Description |
4-PH alpha-3|C-P4H alpha III|collagen prolyl 4-hydroxylase alpha(III)|procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III|prolyl 4-hydroxylase subunit alpha-3
|
| Swissprots |
B4DUD3 Q5JPA9 Q5EBL3 Q7Z4N8 A0AV13
|
| Accessions |
EAW74934 EAW74935 EAW74936 Q7Z4N8 AK300598 BAG62295 AL833965 CAI46215 AY313448 AAQ87603 AY327887 AAP97874 AY358521 AAQ88885 BC040582 BC089446 AAH89446 BC117333 AAI17334 BC126170 AAI26171 HY004548 HY188166 XM_005273924 XP_005273981 XM_011544951 XP_011543253 XM_011544952 XP_011543254 XR_949888 XR_949889 NM_001288748 NP_001275677 NM_182904 NP_878907 NR_110031
|
| Function |
Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:12874193, ECO:0000269|PubMed:14500733}.
|
| Subcellular Location |
Endoplasmic reticulum lumen {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in placenta, liver and fetal skin. Weakly expressed in fetal epiphyseal cartilage, fetal liver, fibroblast, lung and skeletal muscle. Expressed also in fibrous cap of carotid atherosclerotic lesions. {ECO:0000269|PubMed:12874193, ECO:0000269|PubMed:14500733}.
|
| Top Pathways |
Arginine and proline metabolism
|
![Western Blot: P4HA3 Overexpression Lysate (Adult Normal) [NBL1-14053] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for P4HA3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/12263_P4HA3%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14053-img0002.jpg)