Gene Symbol | P4HA3 |
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Entrez Gene | 283208 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | prolyl 4-hydroxylase, alpha polypeptide III |
Other Description | 4-PH alpha-3|C-P4H alpha III|collagen prolyl 4-hydroxylase alpha(III)|procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide III|prolyl 4-hydroxylase subunit alpha-3 |
Swissprots | B4DUD3 Q5JPA9 Q5EBL3 Q7Z4N8 A0AV13 |
Accessions | EAW74934 EAW74935 EAW74936 Q7Z4N8 AK300598 BAG62295 AL833965 CAI46215 AY313448 AAQ87603 AY327887 AAP97874 AY358521 AAQ88885 BC040582 BC089446 AAH89446 BC117333 AAI17334 BC126170 AAI26171 HY004548 HY188166 XM_005273924 XP_005273981 XM_011544951 XP_011543253 XM_011544952 XP_011543254 XR_949888 XR_949889 NM_001288748 NP_001275677 NM_182904 NP_878907 NR_110031 |
Function | Catalyzes the post-translational formation of 4- hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. {ECO:0000269|PubMed:12874193, ECO:0000269|PubMed:14500733}. |
Subcellular Location | Endoplasmic reticulum lumen {ECO:0000305}. |
Tissue Specificity | Highly expressed in placenta, liver and fetal skin. Weakly expressed in fetal epiphyseal cartilage, fetal liver, fibroblast, lung and skeletal muscle. Expressed also in fibrous cap of carotid atherosclerotic lesions. {ECO:0000269|PubMed:12874193, ECO:0000269|PubMed:14500733}. |
Top Pathways | Arginine and proline metabolism |
P4HA3 CRISPR/Cas9 KO Plasmid (h) - sc-410655 from Santa Cruz Biotechnology
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P4HA3 HDR Plasmid (h) - sc-410655-HDR from Santa Cruz Biotechnology
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P4HA3 Double Nickase Plasmid (h) - sc-410655-NIC from Santa Cruz Biotechnology
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P4HA3 Double Nickase Plasmid (h2) - sc-410655-NIC-2 from Santa Cruz Biotechnology
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P4HA3 CRISPR Activation Plasmid (h) - sc-410655-ACT from Santa Cruz Biotechnology
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P4HA3 CRISPR Activation Plasmid (h2) - sc-410655-ACT-2 from Santa Cruz Biotechnology
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P4HA3 Lentiviral Activation Particles (h) - sc-410655-LAC from Santa Cruz Biotechnology
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P4HA3 Lentiviral Activation Particles (h2) - sc-410655-LAC-2 from Santa Cruz Biotechnology
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P4HA3 siRNA (h) - sc-97000 from Santa Cruz Biotechnology
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P4HA3 shRNA Plasmid (h) - sc-97000-SH from Santa Cruz Biotechnology
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P4HA3 shRNA (h) Lentiviral Particles - sc-97000-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN16240 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16240 from Sigma-Aldrich
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P4HA3 siRNA (Human) - CRJ6878 from Cohesion Biosciences
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shRNA set against Human P4HA3 (NM_182904.3) - SHH369664 from Creative biogene
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shRNA set against Human P4HA3(NM_182904.3) - SHR076854 from Creative biogene
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Human P4HA3 siRNA - orb277379 from Biorbyt
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P4HA3 shRNA Plasmid (Human) - CHJ6878 from Cohesion Biosciences
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P4HA3 miRNA 3'UTR clone - MiUTR1H-07450 from Creative biogene
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