| Gene Symbol |
CHST13
|
| Entrez Gene |
166012
|
| Alt Symbol |
C4ST3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
carbohydrate (chondroitin 4) sulfotransferase 13
|
| Other Description |
C4ST-3|carbohydrate sulfotransferase 13|chondroitin 4-O-sulfotransferase 3|chondroitin 4-sulfotransferase 3
|
| Swissprots |
Q8NET6 Q3SYA3 Q3SYA5
|
| Accessions |
EAW79359 Q8NET6 AY120869 AAM55481 BC039390 AAH39390 BC045257 BC047236 AAH47236 BC103895 AAI03896 BC103896 AAI03897 BC103897 AAI03898 DR006930 NM_152889 NP_690849
|
| Function |
Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan.
|
| Subcellular Location |
Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Highly expressed in adult liver. Expressed at lower level in kidney, lymph nodes and fetal kidney. {ECO:0000269|PubMed:12080076}.
|
| Top Pathways |
Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
|