Gene Symbol | CHST13 |
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Entrez Gene | 166012 |
Alt Symbol | C4ST3 |
Species | Human |
Gene Type | protein-coding |
Description | carbohydrate (chondroitin 4) sulfotransferase 13 |
Other Description | C4ST-3|carbohydrate sulfotransferase 13|chondroitin 4-O-sulfotransferase 3|chondroitin 4-sulfotransferase 3 |
Swissprots | Q8NET6 Q3SYA3 Q3SYA5 |
Accessions | EAW79359 Q8NET6 AY120869 AAM55481 BC039390 AAH39390 BC045257 BC047236 AAH47236 BC103895 AAI03896 BC103896 AAI03897 BC103897 AAI03898 DR006930 NM_152889 NP_690849 |
Function | Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Transfers sulfate to the C4 hydroxyl of beta1,4-linked GalNAc that is substituted with a beta-linked glucuronic acid at the C-3 hydroxyl. No activity toward dermatan. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Highly expressed in adult liver. Expressed at lower level in kidney, lymph nodes and fetal kidney. {ECO:0000269|PubMed:12080076}. |
Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
CHST13 CRISPR/Cas9 KO Plasmid (h) - sc-414888 from Santa Cruz Biotechnology
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CHST13 HDR Plasmid (h) - sc-414888-HDR from Santa Cruz Biotechnology
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CHST13 Double Nickase Plasmid (h) - sc-414888-NIC from Santa Cruz Biotechnology
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CHST13 Double Nickase Plasmid (h2) - sc-414888-NIC-2 from Santa Cruz Biotechnology
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CHST13 CRISPR Activation Plasmid (h) - sc-414888-ACT from Santa Cruz Biotechnology
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CHST13 CRISPR Activation Plasmid (h2) - sc-414888-ACT-2 from Santa Cruz Biotechnology
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CHST13 Lentiviral Activation Particles (h) - sc-414888-LAC from Santa Cruz Biotechnology
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CHST13 Lentiviral Activation Particles (h2) - sc-414888-LAC-2 from Santa Cruz Biotechnology
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C4ST-3 siRNA (h) - sc-62114 from Santa Cruz Biotechnology
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C4ST-3 shRNA Plasmid (h) - sc-62114-SH from Santa Cruz Biotechnology
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C4ST-3 shRNA (h) Lentiviral Particles - sc-62114-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN6107 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6107 from Sigma-Aldrich
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CHST13 siRNA (Human) - CRJ6037 from Cohesion Biosciences
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CHST13 - MBS8214317 from MyBioSource
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shRNA set against Human CHST13 (NM_152889.2) - SHH263753 from Creative biogene
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CHST13 shRNA Plasmid (Human) - CHJ6037 from Cohesion Biosciences
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CHST13 miRNA 3'UTR clone - MiUTR3H-11044 from Creative biogene
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