PLCD4

Gene Symbol PLCD4
Entrez Gene 84812
Alt Symbol -
Species Human
Gene Type protein-coding
Description phospholipase C, delta 4
Other Description 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4|PLC delta4|phosphoinositide phospholipase C-delta-4
Swissprots Q9BRC7 Q53FS8
Accessions CBF62952 CBF74703 CBU87828 CBU96775 EAW70627 EAW70628 EAW70629 Q9BRC7 AB209599 BAD92836 AI914254 AK023083 AK057186 AK223203 BAD96923 AK297808 BAG60146 AK299458 BAH13040 AY512961 AAS82574 BC006355 AAH06355 BP361394 DQ895904 ABM86830 EU176403 ABW03854 XM_005246913 XP_005246970 XM_005246915 XP_005246972 XM_011512008 XP_011510310 XM_011512009 XP_011510311 XM_011512010 XP_011510312 XM_011512011 XP_011510313 XM_011512012 XP_011510314 XM_011512013 XP_011510315 XR_241325 NM_032726 NP_116115
Function Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269|PubMed:15140260}.
Subcellular Location Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:15140260}. Endoplasmic reticulum {ECO:0000250}. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
Tissue Specificity Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells. {ECO:0000269|PubMed:15140260, ECO:0000269|PubMed:15505048}.
Top Pathways Calcium signaling pathway, Inositol phosphate metabolism, Phosphatidylinositol signaling system

PLC δ4 (H-250) - sc-30063 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PLC δ4 (H-250): sc-30063. Immunoperoxidase staining of formalin fixed, paraffin-embedded human skeletal muscle tissue showing cytoplasmic staining of myocytes at low (A) and high (B) magnification. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

PLC δ4 (Q-15) - sc-30830 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PLCD4 antibody - ab169169 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-PLCD4 antibody (ab169169) at 1/500 dilutionLane 1 : PLCD4 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat anti-mouse HRP at 1/2500 dilution

Anti-PLCD4 antibody - ab172897 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PLCD4 antibody (ab172897) at 1 µg/ml + Human kidney lysate at 50 µgSecondaryGoat Anti-Rabbit IgG (H+L), Peroxidase Conjugated at 1/7500 dilutiondeveloped using the ECL technique

Anti-PLCD4 antibody - ab57909 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57909 PLCD4 antibody at 1ug/ml.

Anti-PLCD4 antibody - ab101148 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

PLCD4 Antibody - NBP2-38393 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PLCD4 Antibody - H00084812-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: PLCD4 Antibody [H00084812-B01] - analysis of PLCD4 expression in transfected 293T cell line by PLCD4 MaxPab polyclonal antibody (B01). Lane 1: PLCD4 transfected lysate (87.60 KDa). Lane 2: Non-transfected lysate.

PLCD4 Antibody - NBP2-38392 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: PLCD4 Antibody [NBP2-38392] - Staining of human skeletal muscle shows cytoplasmic positivity in myocytes.

PLCD4 Antibody (4D4) - H00084812-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4D4
Western Blot: PLCD4 Antibody (4D4) [H00084812-M01] - Analysis of PLCD4 expression in transfected 293T cell line by PLCD4 monoclonal antibody (M01), clone 4D4.Lane 1: PLCD4 transfected lysate (Predicted MW: 87.6 KDa).Lane 2: Non-transfected lysate.

PLCD4 Antibody - H00084812-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: PLCD4 Antibody [H00084812-D01P] - Analysis of PLCD4 expression in human kidney.

PLCD4 Antibody - NBP1-31867 from Novus Biologicals

Host Rabbit
Clonality Polyclonal

Anti-PLCD4 antibody produced in rabbit - SAB1411521 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PLCD4: <B>Cat. No. SAB1411521</B>: Antibody concentration: 0.1-5 μg/mL. Specific band of ~87.6 kDa using PLCD4 transfected 293T lysate.<BR/><B>Lanes</B><BR/>1. Transfected 293T lysate.<BR/>2. Non-transfected 293T lysate.

Monoclonal Anti-PLCD4 antibody produced in mouse - WH0084812M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4D4
<B>Immunoblotting</B><BR/>Monoclonal Anti-PLCD4, <B>Cat. No. WH0084812M1</B> used at the antibody concentration: 1 μg/mL. Specific band of ~38.21 kDa using immunogen protein lysate.

Anti-PLCD4 (141-155) antibody produced in rabbit - SAB1105923 from Sigma-Aldrich

Prices $279.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human PLCD4 was separated on SDS-PAGE, blotted with Anti-PLCD4 (141-155) (<B>Cat. No. SAB1105923</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000

PLCD4-Antibody-monoclonal-M01 - AT3334a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4D4
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .

PLCD4 antibody - 70R-19334 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

PLCD4 antibody - 10589-2-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded Pancreas cancer using 10589-2-AP(PLCD4 Antibody) at Dilution 1:50 (under 10x lens)

PLCD4 antibody - H00084812-B01 from Acris Antibodies

Prices $360.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot analysis of PLCD4 expression in transfected 293T cell line (H00084812-T01) by PLCD4 MaxPab polyclonal antibody.Lane 1: PLCD4 tra

PLCD4 antibody - H00084812-D01P from Acris Antibodies

Prices $390.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot analysis of PLCD4 expression in transfected 293T cell line (H00084812-T02) by PLCD4 MaxPab polyclonal antibody. Lane 1: PLCD4 transfected lysate(87.60 KDa). Lane 2: Non-transfected lysate.

PLCD4 antibody - H00084812-M01 from Acris Antibodies

Prices $360.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4D4
Detection limit for recombinant GST tagged PLCD4 is approximately 0.3ng/ml as a capture antibody.

PLCD4 antibody - 10589-2-AP from Proteintech Group

Prices $279.00
Sizes con: 20 μg/150μl
Host Rabbit
Clonality Polyclonal
Immunohistochemical of paraffin-embedded human pancreas cancer using 10589-2-AP(PLCD4 antibody) at dilution of 1:50 (under 10x lens)

Anti-PLCD4 (full length) polyclonal antibody - DPABH-07786 from Creative Diagnostics

Host Mouse
Clonality Polyclonal

Rabbit anti-Human PLCD4 polyclonal antibody - DPABH-10175 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

phospholipase C, delta 4 , Polyclonal Antibody - MBS713680 from MyBioSource

Prices $230.00, $500.00
Sizes 50 µl, 150 µl
Host Rabbit
Clonality Polyclonal
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