| Gene Symbol |
PLCD4
|
| Entrez Gene |
84812
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phospholipase C, delta 4
|
| Other Description |
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4|PLC delta4|phosphoinositide phospholipase C-delta-4
|
| Swissprots |
Q9BRC7 Q53FS8
|
| Accessions |
CBF62952 CBF74703 CBU87828 CBU96775 EAW70627 EAW70628 EAW70629 Q9BRC7 AB209599 BAD92836 AI914254 AK023083 AK057186 AK223203 BAD96923 AK297808 BAG60146 AK299458 BAH13040 AY512961 AAS82574 BC006355 AAH06355 BP361394 DQ895904 ABM86830 EU176403 ABW03854 XM_005246913 XP_005246970 XM_005246915 XP_005246972 XM_011512008 XP_011510310 XM_011512009 XP_011510311 XM_011512010 XP_011510312 XM_011512011 XP_011510313 XM_011512012 XP_011510314 XM_011512013 XP_011510315 XR_241325 NM_032726 NP_116115
|
| Function |
Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269|PubMed:15140260}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:15140260}. Endoplasmic reticulum {ECO:0000250}. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
|
| Tissue Specificity |
Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells. {ECO:0000269|PubMed:15140260, ECO:0000269|PubMed:15505048}.
|
| Top Pathways |
Calcium signaling pathway, Inositol phosphate metabolism, Phosphatidylinositol signaling system
|