PLCD4

Gene Symbol	PLCD4
Entrez Gene	84812
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	phospholipase C, delta 4
Other Description	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4|1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-4|PLC delta4|phosphoinositide phospholipase C-delta-4
Swissprots	Q9BRC7 Q53FS8
Accessions	CBF62952 CBF74703 CBU87828 CBU96775 EAW70627 EAW70628 EAW70629 Q9BRC7 AB209599 BAD92836 AI914254 AK023083 AK057186 AK223203 BAD96923 AK297808 BAG60146 AK299458 BAH13040 AY512961 AAS82574 BC006355 AAH06355 BP361394 DQ895904 ABM86830 EU176403 ABW03854 XM_005246913 XP_005246970 XM_005246915 XP_005246972 XM_011512008 XP_011510310 XM_011512009 XP_011510311 XM_011512010 XP_011510312 XM_011512011 XP_011510313 XM_011512012 XP_011510314 XM_011512013 XP_011510315 XR_241325 NM_032726 NP_116115
Function	Hydrolyzes the phosphatidylinositol 4,5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). DAG mediates the activation of protein kinase C (PKC), while IP3 releases Ca(2+) from intracellular stores. Required for acrosome reaction in sperm during fertilization, probably by acting as an important enzyme for intracellular Ca(2+) mobilization in the zona pellucida- induced acrosome reaction. May play a role in cell growth. Modulates the liver regeneration in cooperation with nuclear PKC. Overexpression up-regulates the Erk signaling pathway and proliferation. {ECO:0000269|PubMed:15140260}.
Subcellular Location	Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:15140260}. Endoplasmic reticulum {ECO:0000250}. Note=Localizes primarily to intracellular membranes mostly to the endoplasmic reticulum.
Tissue Specificity	Highly expressed in skeletal muscle and kidney tissues, and at moderate level in intestinal tissue. Expressed in corneal epithelial cells. {ECO:0000269|PubMed:15140260, ECO:0000269|PubMed:15505048}.
Top Pathways	Calcium signaling pathway, Inositol phosphate metabolism, Phosphatidylinositol signaling system

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PLCD4 full length protein - ab164661 from Abcam Category Protein Source Wheat germ Species Human

Human PLCD4 full length protein - ab164662 from Abcam Category Protein Source Wheat germ Species Human

Human PLCD4 protein fragment - ab164663 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human PLCD4 Protein - H00084812-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PLCD4 Protein - H00084812-P02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human PLCD4 Protein - H00084812-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

PLCD4-Antibody-C-term-Blocking-Peptide - BP17424b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human PLCD4 protein - orb246633 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

PLCD4 - H00084812-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PLCD4 - H00084812-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PLCD4 - H00084812-P02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

PLCD4 - H00084812-P02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PLCD4 - H00084812-P02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PLCD4 - H00084812-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PLCD4 - H00084812-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PLCD4 fusion protein - ag0937 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4(PLCD4) - CSB-YP866264HU CSB-BP866264HU CSB-MP866264HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delt - CSB-EP866264HU from Cusabio Category Protein Source E.coli Species Human

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4, Recombinant Protein - MBS1367818 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $1,180.00, $1,575.00, $1,805.00, $1,805.00, $2,720.00, $3,160.00, $3,160.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell

PLCD4 Protein - abx163057 from Abbexa Category Protein Species Human

PLCD4 - TP302935 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

PLCD4 Recombinant Protein Antigen - NBP2-38393PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PLCD4 Recombinant Protein Antigen - NBP2-38392PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

PLCD4 Peptide, Human - M34GP11900H from Creative Peptides Category Peptide Source Synthetic. Species Human

PLCD4 Recombinant Protein (OPCA02476) - OPCA02476 from Aviva Systems Biology Category Protein Prices $250.00 Sizes 50 µg Source Human

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