DIS3

Gene Symbol DIS3
Entrez Gene 22894
Alt Symbol 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p
Species Human
Gene Type protein-coding
Description DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
Other Description DIS3 mitotic control homolog|exosome complex exonuclease RRP44|exosome component 11|mitotic control protein dis3 homolog|ribosomal RNA-processing protein 44
Swissprots Q658Z7 A6NI21 Q9Y2L1 Q7Z481 B2RBL2 Q5W0P7 Q8WWI2 Q5W0P8 Q9UG36
Accessions EAW80517 EAW80518 EAW80519 EAW80520 EAW80521 Q9Y2L1 AB001743 BAF92610 AB023225 BAA76852 AF035310 AF330044 AAL37479 AK001346 BAG50895 AK025634 AK314715 BAG37259 AL080158 CAB45749 AL832266 CAH56266 BC012468 BC038101 AAH38101 BC056143 AAH56143 DB075344 DB091752 U79246 XM_005266294 XP_005266351 XM_006719778 XP_006719841 NM_001128226 NP_001121698 NM_014953 NP_055768
Function Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pat
Subcellular Location Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in the nucleus. According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3.
Tissue Specificity Widely expressed.
Top Pathways RNA degradation

DIS3 (P-18) - sc-84082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
DIS3 (P-18): sc-84082. Western blot analysis of DIS3 expression in Jurkat nuclear extract (A) and rat brain tissue extract (B).

DIS3 (H-3) - sc-398663 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DIS3 (H-3): sc-398663. Western blot analysis of DIS3 expression in HeLa (A) and Jurkat (B) nuclear extracts and human liver tissue extract (C).

DIS3 (H-171) - sc-367316 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DIS3 (H-171): sc-367316. Western blot analysis of DIS3 expression in HeLa nuclear extract.

DIS3 (T-20) - sc-84083 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
DIS3 (T-20): sc-84083. Western blot analysis of DIS3 expression in non-transfected: sc-117752 (A) and human DIS3 transfected: sc-116575 (B) 293T whole cell lysates.

Anti-DIS3 antibody - ab68570 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-DIS3 antibody (ab68570) at 1/500 dilutionLane 1 : DIS3 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Anti-DIS3 antibody - ab179933 from Abcam

Prices $376.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human skin tissue labelling DIS3 with ab179933 at 5µg/ml.

Anti-DIS3 antibody - ab176802 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-DIS3 antibody (ab176802) at 0.1 µg/mlLane 1 : HeLa whole cell lysate at 50 µgLane 2 : HeLa whole cell lysate at 15 µgLane 3 : 293T whole cell lysate at 50 µgLane 4 : Jurkat whole cell lysate at 50 µgdeveloped using the ECL technique

Anti-DIS3 antibody - ab184125 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemical analysis of NT2D1 cells fixed in 4% paraformaldehye at room temperature for 15 mins labeling DIS3 with ab184125 at 1/500 dilution (green) and counterstained with Hoechst 33342 (blue)

Anti-DIS3 antibody - N-terminal - ab167117 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-DIS3 antibody - N-terminal (ab167117) at 1 µg/ml + Human ovarian tissue lysate at 15 µg

Anti-DIS3 Antibody (aa302-331, AP) - LS-C208801 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIS3 Antibody (aa302-331, APC) - LS-C208802 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIS3 Antibody (aa302-331, Biotin) - LS-C208803 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIS3 Antibody (aa302-331, FITC) - LS-C208804 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIS3 Antibody (aa290-339) - LS-C80373 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 6-18%.

Anti-DIS3 Antibody (aa302-331, Azide-free, HRP) - LS-C208805 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIS3 Antibody (aa92-141) - LS-C187155 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Esophagus Tumor. DIS3 antibody dilution 1.0 ug/ml.

Anti-DIS3 Antibody (aa302-331, PE) - LS-C208806 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIS3 Antibody (aa1-50) - LS-C290419 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DIS3 Antibody (aa858-908) - LS-C290420 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DIS3 Antibody - LS-C307873 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-DIS3 Antibody (aa861-957) - LS-C307890 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DIS3 Antibody (aa908-958) - LS-C290423 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DIS3 Antibody (aa295-323) IHC-plus™ - LS-B9159 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Human, Skin; Formalin-Fixed Paraffin-Embedded (FFPE)

Anti-DIS3 Antibody (aa302-331) - LS-C320847 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DIS3 Antibody (N-Terminus) IHC-plus™ - LS-B10106 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-DIS3 antibody IHC staining of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10106 concentration 10 ug/ml.
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