DIS3

Gene Symbol	DIS3
Entrez Gene	22894
Alt Symbol	2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p
Species	Human
Gene Type	protein-coding
Description	DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
Other Description	DIS3 mitotic control homolog|exosome complex exonuclease RRP44|exosome component 11|mitotic control protein dis3 homolog|ribosomal RNA-processing protein 44
Swissprots	Q658Z7 A6NI21 Q9Y2L1 Q7Z481 B2RBL2 Q5W0P7 Q8WWI2 Q5W0P8 Q9UG36
Accessions	EAW80517 EAW80518 EAW80519 EAW80520 EAW80521 Q9Y2L1 AB001743 BAF92610 AB023225 BAA76852 AF035310 AF330044 AAL37479 AK001346 BAG50895 AK025634 AK314715 BAG37259 AL080158 CAB45749 AL832266 CAH56266 BC012468 BC038101 AAH38101 BC056143 AAH56143 DB075344 DB091752 U79246 XM_005266294 XP_005266351 XM_006719778 XP_006719841 NM_001128226 NP_001121698 NM_014953 NP_055768
Function	Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pat
Subcellular Location	Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in the nucleus. According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3.
Tissue Specificity	Widely expressed.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DIS3 protein fragment - ab161467 from Abcam Category Protein Source Wheat germ Species Human

DIS3 Antibody Blocking Peptide - LS-E104 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DIS3 Antibody Blocking Peptide - LS-E14951 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DIS3 Antibody Blocking Peptide - LS-E14950 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DIS3 Antibody Blocking Peptide - LS-E31438 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human DIS3 Protein - H00022894-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DIS3-Antibody-Center-Blocking-peptide - BP10196c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

DIS3 Blocking Peptide - 33R-2010 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

DIS3 - H00022894-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DIS3 - H00022894-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DIS3 Peptide - 7343P from ProSci Category Peptide Species Human

DIS3 fusion protein - Ag6587 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DIS3 fusion protein - Ag6117 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human DIS3, His-tagged - DIS3-12004H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Exosome complex exonuclease RRP44(DIS3) ,partial - CSB-YP897532HU CSB-EP897532HU CSB-BP897532HU CSB-MP897532HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

DIS3 Protein - abx164924 from Abbexa Category Protein Species Human, Mouse, Rat

DIS3 (transcript variant 1) - TP308907 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

DIS3 Recombinant Protein Antigen - NBP1-85209PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DIS3 Peptide, Human - M34GP04319H from Creative Peptides Category Peptide Source Synthetic. Species Human

DIS3 Recombinant Protein Antigen - NBP2-55359PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Exosome complex exonuclease RRP44 (DIS3), partial, Recombinant Protein - MBS1350446 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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