| Gene Symbol | DIS3 |
|---|---|
| Entrez Gene | 22894 |
| Alt Symbol | 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p |
| Species | Human |
| Gene Type | protein-coding |
| Description | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease |
| Other Description | DIS3 mitotic control homolog|exosome complex exonuclease RRP44|exosome component 11|mitotic control protein dis3 homolog|ribosomal RNA-processing protein 44 |
| Swissprots | Q658Z7 A6NI21 Q9Y2L1 Q7Z481 B2RBL2 Q5W0P7 Q8WWI2 Q5W0P8 Q9UG36 |
| Accessions | EAW80517 EAW80518 EAW80519 EAW80520 EAW80521 Q9Y2L1 AB001743 BAF92610 AB023225 BAA76852 AF035310 AF330044 AAL37479 AK001346 BAG50895 AK025634 AK314715 BAG37259 AL080158 CAB45749 AL832266 CAH56266 BC012468 BC038101 AAH38101 BC056143 AAH56143 DB075344 DB091752 U79246 XM_005266294 XP_005266351 XM_006719778 XP_006719841 NM_001128226 NP_001121698 NM_014953 NP_055768 |
| Function | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pat |
| Subcellular Location | Cytoplasm. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus. Note=Predominantly located in the nucleus. According to PubMed:12429849, found in the nucleolus and according to PubMed:20531386, excluded from nucleolus supporting the existence of a nucleolar RNA exosome complex devoid of DIS3. |
| Tissue Specificity | Widely expressed. |
| Top Pathways | RNA degradation |
DIS3 mitotic control homolog (S. cerevisiae) , ELISA Kit - MBS9342350 from MyBioSource
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Human DIS3 ELISA Kit - E096426 from Biobool
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Human Exosome complex exonuclease RRP44 (DIS3) ELISA Kit - AE47211HU from ARP American Research Products
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Exosome Complex Exonuclease RRP44 (DIS3), ELISA Kit - MBS9370655 from MyBioSource
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Exosome Complex Exonuclease RRP44 (DIS3), ELISA Kit - MBS9371177 from MyBioSource
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Exosome Complex Exonuclease RRP44 (DIS3), ELISA Kit - MBS9374915 from MyBioSource
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Exosome Complex Exonuclease RRP44 (DIS3), ELISA Kit - MBS9380217 from MyBioSource
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Exosome Complex Exonuclease RRP44 (DIS3), ELISA Kit - MBS9379562 from MyBioSource
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Exosome Complex Exonuclease RRP44 (DIS3), ELISA Kit - MBS9379637 from MyBioSource
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Exosome Complex Exonuclease RRP44 (DIS3), ELISA Kit - MBS9378730 from MyBioSource
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