| Gene Symbol | MBP |
|---|---|
| Entrez Gene | 4155 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | myelin basic protein |
| Other Description | myelin A1 protein|myelin membrane encephalitogenic protein |
| Swissprots | B7ZKS4 A8MY86 Q6FI04 Q59GX3 B3KY66 B7ZKS2 Q6AI64 Q15339 Q6PK23 Q65ZS4 A8MYL4 Q15338 A6NI84 Q15340 Q15337 P02686 A4FU54 Q6FH37 |
| Accessions | AAA59560 AAA72008 AAA72009 AAA72011 AAC41944 CAA35179 CAH10321 CAJ75954 CBL86565 CBX47515 CBX47516 CBX47517 CBX47518 CBX47519 CBX47520 EAW66592 EAW66593 EAW66594 EAW66595 EAW66596 EAW66597 EAW66598 EAW66599 EAW66600 P02686 AB208986 BAD92223 AK074315 AK093588 AK094611 AK095121 AK098402 AK098513 AK122594 BAG53615 AK123433 BAC85616 AK124830 BAC85961 AK126858 AK128770 BAG54728 AK128788 BAG54734 AK289893 BAF82582 AK293922 BAG57303 AK296492 BAH12372 AK314553 BC008749 AAH08749 BC030093 BC065248 AAH65248 BC068550 BC080654 AAH80654 BC101771 AAI01772 BC101773 AAI01774 BC130034 BC143348 AAI43349 BC143350 AAI43351 BG766942 BM977768 BU430656 CB153535 CB156561 CR536534 CAG38771 CR541919 CAG46717 CR627018 CAH10359 L18865 AAA72010 M13577 AAA59562 M20009 AAA59561 M30047 AAA59559 M30515 AAA59564 M30516 AAA59563 N20370 XM_011526008 XP_011524310 XM_011526009 XP_011524311 XM_011526010 XP_011524312 XM_011526011 XP_011524313 XM_011526012 XP_011524314 XR_245460 XR_245461 NM_001025081 NP_001020252 NM_001025090 NP_001020261 NM_001025092 NP_001020263 NM_001025100 NP_001020271 NM_001025101 NP_001020272 NM_002385 NP_002376 NM_001025094 NM_001025098 |
| Function | The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}. |
| Subcellular Location | Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin. |
| Tissue Specificity | MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. {ECO:0000269|PubMed:7504278}. |
MBP CRISPR/Cas9 KO Plasmid (h) - sc-400331 from Santa Cruz Biotechnology
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MBP HDR Plasmid (h) - sc-400331-HDR from Santa Cruz Biotechnology
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MBP Double Nickase Plasmid (h) - sc-400331-NIC from Santa Cruz Biotechnology
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MBP Double Nickase Plasmid (h2) - sc-400331-NIC-2 from Santa Cruz Biotechnology
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MBP CRISPR Activation Plasmid (h) - sc-400331-ACT from Santa Cruz Biotechnology
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MBP CRISPR Activation Plasmid (h2) - sc-400331-ACT-2 from Santa Cruz Biotechnology
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MBP Lentiviral Activation Particles (h) - sc-400331-LAC from Santa Cruz Biotechnology
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MBP Lentiviral Activation Particles (h2) - sc-400331-LAC-2 from Santa Cruz Biotechnology
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MBP siRNA (h) - sc-35871 from Santa Cruz Biotechnology
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MBP shRNA Plasmid (h) - sc-35871-SH from Santa Cruz Biotechnology
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MBP shRNA (h) Lentiviral Particles - sc-35871-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU095491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13093 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13093 from Sigma-Aldrich
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MBP siRNA (Human) - CRH2828 from Cohesion Biosciences
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shRNA set against Human MBP (NM_002385.2) - SHH338979 from Creative biogene
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Human MBP siRNA - orb263330 from Biorbyt
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MBP shRNA Plasmid (Human) - CHH2828 from Cohesion Biosciences
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MBP miRNA 3'UTR clone - MiUTR1H-06142 from Creative biogene
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MBP miRNA 3'UTR clone - MiUTR1H-06143 from Creative biogene
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MBP miRNA 3'UTR clone - MiUTR1H-06144 from Creative biogene
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MBP miRNA 3'UTR clone - MiUTR1H-06145 from Creative biogene
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MBP miRNA 3'UTR clone - MiUTR1H-06146 from Creative biogene
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MBP miRNA 3'UTR clone - MiUTR1H-06147 from Creative biogene
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