MBP

Gene Symbol MBP
Entrez Gene 4155
Alt Symbol -
Species Human
Gene Type protein-coding
Description myelin basic protein
Other Description myelin A1 protein|myelin membrane encephalitogenic protein
Swissprots B7ZKS4 A8MY86 Q6FI04 Q59GX3 B3KY66 B7ZKS2 Q6AI64 Q15339 Q6PK23 Q65ZS4 A8MYL4 Q15338 A6NI84 Q15340 Q15337 P02686 A4FU54 Q6FH37
Accessions AAA59560 AAA72008 AAA72009 AAA72011 AAC41944 CAA35179 CAH10321 CAJ75954 CBL86565 CBX47515 CBX47516 CBX47517 CBX47518 CBX47519 CBX47520 EAW66592 EAW66593 EAW66594 EAW66595 EAW66596 EAW66597 EAW66598 EAW66599 EAW66600 P02686 AB208986 BAD92223 AK074315 AK093588 AK094611 AK095121 AK098402 AK098513 AK122594 BAG53615 AK123433 BAC85616 AK124830 BAC85961 AK126858 AK128770 BAG54728 AK128788 BAG54734 AK289893 BAF82582 AK293922 BAG57303 AK296492 BAH12372 AK314553 BC008749 AAH08749 BC030093 BC065248 AAH65248 BC068550 BC080654 AAH80654 BC101771 AAI01772 BC101773 AAI01774 BC130034 BC143348 AAI43349 BC143350 AAI43351 BG766942 BM977768 BU430656 CB153535 CB156561 CR536534 CAG38771 CR541919 CAG46717 CR627018 CAH10359 L18865 AAA72010 M13577 AAA59562 M20009 AAA59561 M30047 AAA59559 M30515 AAA59564 M30516 AAA59563 N20370 XM_011526008 XP_011524310 XM_011526009 XP_011524311 XM_011526010 XP_011524312 XM_011526011 XP_011524313 XM_011526012 XP_011524314 XR_245460 XR_245461 NM_001025081 NP_001020252 NM_001025090 NP_001020261 NM_001025092 NP_001020263 NM_001025100 NP_001020271 NM_001025101 NP_001020272 NM_002385 NP_002376 NM_001025094 NM_001025098
Function The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non- classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T- cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation. {ECO:0000269|PubMed:8544862}.
Subcellular Location Myelin membrane; Peripheral membrane protein; Cytoplasmic side. Note=Cytoplasmic side of myelin.
Tissue Specificity MBP isoforms are found in both the central and the peripheral nervous system, whereas Golli-MBP isoforms are expressed in fetal thymus, spleen and spinal cord, as well as in cell lines derived from the immune system. {ECO:0000269|PubMed:7504278}.

Myelin Basic Protein (2H9) Mouse mAb - 13344 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 2H9
Western blot analysis of extracts from rat brain and KNRK cells using Myelin Basic Protein (2H9) Mouse mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

MBP (A-3) - sc-376995 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MBP (A-3): sc-376995. Western blot analysis of MBP expression in mouse brain (A) and rat brain (B) tissue extracts.

MBP (C-1) - sc-398212 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MBP (C-1): sc-398212. Western blot analysis of MBP expression in human brain tissue extract.

MBP (C-16) - sc-13914 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MBP (C-16): sc-13914. Western blot analysis of MBP isoform expression in rat (A) and mouse (B) brain tissue extracts.

MBP (D-18) - sc-13912 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MBP (D-18): sc-13912. Western blot analysis of MBP isoform expression in rat (A) and mouse (B) brain tissue extracts.

MBP (F-6) - sc-271524 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MBP (F-6): sc-271524. Western blot analysis of MBP expression in mouse brain tissue extract.

MBP (FL-304) - sc-25665 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MBP (FL-304): sc-25665. Western blot analysis of MBP expression in mouse brain tissue extract.

MBP (I-15) - sc-31526 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MBP (I-15): sc-31526. Western blot analysis of MBP expression in mouse brain tissue extract.

MBP (P-17) - sc-31527 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MBP (K-16) - sc-31528 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MBP (K-16): sc-31528. Western blot analysis of MBP expression in mouse brain tissue extract.

MBP (26) - sc-58542 from Santa Cruz Biotechnology

Prices $279.00
Sizes 1000 µl supernatant
Host Mouse
Clonality Monoclonal
MBP (26): sc-58542. Western blot analysis of MBP expression in non-transfected: sc-117752 (A) and mouse MBP transfected: sc-121552 (B) 293T whole cell lysates.

MBP (1.B.645) - sc-71546 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
MBP (1.B.645): sc-71546. Western blot analysis of MBP expression in non-transfected: sc-117752 (A) and mouse MBP transfected: sc-121552 (B) 293T whole cell lysates and mouse brain tissue extract (C).

MBP (201) - sc-66064 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
MBP (201): sc-66064. Western blot analysis of MBP expression in non-transfected: sc-117752 (A) and mouse MBP transfected: sc-121552 (B) 293T whole cell lysates and mouse brain tissue extract (C).

p-MBP (D-11) - sc-365621 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
p-MBP (D-11): sc-365621. Immunoperoxidase staining of formalin fixed, paraffin-embedded human brain tissue showing cytoplasmic staining of neuronal cells and nerve fibers.

Anti-Myelin Basic Protein antibody - ab85887 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-Myelin Basic Protein antibody - ab134018 from Abcam

Prices $376.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
Immunohistochemical analysis of a section of adult mouse brain labelling Myelin Basic Protein (red staining) of white matter tracts adjacent to the hippocampal formation with ab134018 at 1/1000 dilution. Green staining is autofluorescence from green fluorescent protein (GFP) expressed in this transgenic mouse.

Anti-Myelin Basic Protein antibody - ab124493 from Abcam

Prices $376.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab124493 stained SKNSH cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal Goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab124493, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 Goat anti-Rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-Myelin Basic Protein antibody - ab49208 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Ab49208 (1:2000) staining of myelin basic protein on normal human brain by IHC (5µm thick paraffin-embedded section). Courtesy of Dr Wei-Ping Gai, The Flinders University of South Australia.

Anti-Myelin Basic Protein antibody - ab53439 from Abcam

Prices $376.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal
ab53439 at 1/100 staining Myelin Basic Protein in myelin (red) in cortical white matter from a GFP-expressing transgenic adult mouse, by Immunofluorescence.

Anti-Myelin Basic Protein antibody [22] - ab11223 from Abcam

Prices $376.00
Sizes 1 ml
Host Mouse
Clonality Monoclonal
Clone 22
ab11223 staining Myelin Basic Protein of white matter in human brain section by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Anti-Myelin Basic Protein antibody [5F12-B10] - ab69493 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 5F12-B10

Anti-Myelin Basic Protein antibody [7D2] - ab78157 from Abcam

Prices $384.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 7D2
Anti-Myelin Basic Protein antibody [7D2] (ab78157) at 1/10000 dilution + Crude rat spinal cord homogenate

Anti-Myelin Basic Protein antibody [7G7] - ab78156 from Abcam

Prices $385.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone 7G7
Anti-Myelin Basic Protein antibody [7G7] (ab78156) at 1/10000 dilution + Crude rat spinal cord homogenate

Anti-Myelin Basic Protein antibody [BDI221] - ab66188 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone BDI221
Overlay histogram showing PC12 cells stained with ab66188 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab66188, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG2b [PLPV219] (ab91366, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed. This antibody gave a positive signal in PC12 cells fixed with 4% paraformaldehyde (10 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-Myelin Basic Protein antibody [EPR10144] - ab155995 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR10144
All lanes : Anti-Myelin Basic Protein antibody [EPR10144] (ab155995) at 1/1000 dilutionLane 1 : Mouse brain lysateLane 2 : Rat brain lysateLane 3 : Human fetal lung lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution
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