| Gene Symbol |
HTATSF1
|
| Entrez Gene |
27336
|
| Alt Symbol |
TAT-SF1, TATSF1, dJ196E23.2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HIV-1 Tat specific factor 1
|
| Other Description |
HIV TAT specific factor 1|HIV Tat-specific factor 1|cofactor required for Tat activation of HIV-1 transcription
|
| Swissprots |
Q99730 Q59G06 O43719 D3DWG9
|
| Accessions |
EAW88468 EAW88469 O43719 AB209303 BAD92540 AK225870 AK299403 BAG61386 BC009896 AAH09896 BT006886 AAP35532 BU633070 EU176345 ABW03796 U76992 AAB18823 XM_005262404 XP_005262461 NM_001163280 NP_001156752 NM_014500 NP_055315
|
| Function |
Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:15485897, ECO:0000269|PubMed:8849451}.
|
| Tissue Specificity |
Widely expressed. {ECO:0000269|PubMed:8849451}.
|