Gene Symbol | HTATSF1 |
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Entrez Gene | 27336 |
Alt Symbol | TAT-SF1, TATSF1, dJ196E23.2 |
Species | Human |
Gene Type | protein-coding |
Description | HIV-1 Tat specific factor 1 |
Other Description | HIV TAT specific factor 1|HIV Tat-specific factor 1|cofactor required for Tat activation of HIV-1 transcription |
Swissprots | Q99730 Q59G06 O43719 D3DWG9 |
Accessions | EAW88468 EAW88469 O43719 AB209303 BAD92540 AK225870 AK299403 BAG61386 BC009896 AAH09896 BT006886 AAP35532 BU633070 EU176345 ABW03796 U76992 AAB18823 XM_005262404 XP_005262461 NM_001163280 NP_001156752 NM_014500 NP_055315 |
Function | Functions as a general transcription factor playing a role in the process of transcriptional elongation. May mediate the reciprocal stimulatory effect of splicing on transcriptional elongation. In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus. {ECO:0000269|PubMed:10393184, ECO:0000269|PubMed:10454543, ECO:0000269|PubMed:10913173, ECO:0000269|PubMed:11420046, ECO:0000269|PubMed:11780068, ECO:0000269|PubMed:15905670, ECO:0000269|PubMed:8849451, ECO:0000269|PubMed:9765201}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15485897, ECO:0000269|PubMed:8849451}. |
Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:8849451}. |
HIV Tat-SF1 CRISPR/Cas9 KO Plasmid (h) - sc-404479 from Santa Cruz Biotechnology
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HIV Tat-SF1 HDR Plasmid (h) - sc-404479-HDR from Santa Cruz Biotechnology
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HIV Tat-SF1 Double Nickase Plasmid (h) - sc-404479-NIC from Santa Cruz Biotechnology
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HIV Tat-SF1 Double Nickase Plasmid (h2) - sc-404479-NIC-2 from Santa Cruz Biotechnology
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HIV Tat-SF1 CRISPR Activation Plasmid (h) - sc-404479-ACT from Santa Cruz Biotechnology
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HIV Tat-SF1 CRISPR Activation Plasmid (h2) - sc-404479-ACT-2 from Santa Cruz Biotechnology
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HIV Tat-SF1 Lentiviral Activation Particles (h) - sc-404479-LAC from Santa Cruz Biotechnology
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HIV Tat-SF1 Lentiviral Activation Particles (h2) - sc-404479-LAC-2 from Santa Cruz Biotechnology
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HIV-1 Tat-SF1 siRNA (h) - sc-62468 from Santa Cruz Biotechnology
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HIV-1 Tat-SF1 shRNA Plasmid (h) - sc-62468-SH from Santa Cruz Biotechnology
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HIV-1 Tat-SF1 shRNA (h) Lentiviral Particles - sc-62468-V from Santa Cruz Biotechnology
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HIV TAT specific factor 1 RNAi - H00027336-R01 from Novus Biologicals
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MISSION® esiRNA - EHU103161 from Sigma-Aldrich
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MISSION® esiRNA - EHU000191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10388 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10388 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02852 from Sigma-Aldrich
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HTATSF1 siRNA (Human) - CRH9086 from Cohesion Biosciences
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HTATSF1 - MBS8203019 from MyBioSource
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HIV Tat-SF1 CRISPR/Cas9 KO Plasmid (h2) - sc-404479-KO-2 from Santa Cruz Biotechnology
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HIV Tat-SF1 HDR Plasmid (h2) - sc-404479-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human HTATSF1 (NM_014500.4) - SHH315841 from Creative biogene
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Human HTATSF1 siRNA - orb269588 from Biorbyt
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HTATSF1 shRNA Plasmid (Human) - CHH9086 from Cohesion Biosciences
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HTATSF1 miRNA 3'UTR clone - MiUTR3H-02701 from Creative biogene
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