| Gene Symbol |
UBE2O
|
| Entrez Gene |
63893
|
| Alt Symbol |
E2-230K
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2O
|
| Other Description |
E2/E3 hybrid ubiquitin-protein ligase UBE2O|ubiquitin carrier protein O|ubiquitin-conjugating enzyme E2 of 230 kDa|ubiquitin-conjugating enzyme E2-230K|ubiquitin-protein ligase O
|
| Swissprots |
Q86UA4 Q9H9B2 Q9BSW1 Q8TBN1 Q9H6E6 Q9C0C9 A6NDU5 Q8N425 Q6PIZ2 Q9H7E4 Q69YP4
|
| Accessions |
EAW89395 EAW89396 EAW89397 EAW89398 EAW89399 Q9C0C9 AB051521 BAB21825 AK000926 AK022940 BAB14320 AK024657 BAB14948 AK025999 BAB15313 AK225412 AL832432 CAH10644 BC004525 AAH04525 BC007822 BC022237 AAH22237 BC025977 AAH25977 BC036820 AAH36820 BC051868 AAH51868 DA092358 XM_005257567 XP_005257624 XM_011525107 XP_011523409 XM_011525108 XP_011523410 XM_011525109 XP_011523411 NM_022066 NP_071349
|
| Function |
E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin- associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853,
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:24703950}. Nucleus {ECO:0000269|PubMed:24703950}. Note=Mainly localizes to the cytoplasm.
|
| Tissue Specificity |
Predominantly expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11311559}.
|
| Top Pathways |
Ubiquitin mediated proteolysis
|
