UBE2O

Gene Symbol	UBE2O
Entrez Gene	63893
Alt Symbol	E2-230K
Species	Human
Gene Type	protein-coding
Description	ubiquitin-conjugating enzyme E2O
Other Description	E2/E3 hybrid ubiquitin-protein ligase UBE2O|ubiquitin carrier protein O|ubiquitin-conjugating enzyme E2 of 230 kDa|ubiquitin-conjugating enzyme E2-230K|ubiquitin-protein ligase O
Swissprots	Q86UA4 Q9H9B2 Q9BSW1 Q8TBN1 Q9H6E6 Q9C0C9 A6NDU5 Q8N425 Q6PIZ2 Q9H7E4 Q69YP4
Accessions	EAW89395 EAW89396 EAW89397 EAW89398 EAW89399 Q9C0C9 AB051521 BAB21825 AK000926 AK022940 BAB14320 AK024657 BAB14948 AK025999 BAB15313 AK225412 AL832432 CAH10644 BC004525 AAH04525 BC007822 BC022237 AAH22237 BC025977 AAH25977 BC036820 AAH36820 BC051868 AAH51868 DA092358 XM_005257567 XP_005257624 XM_011525107 XP_011523409 XM_011525108 XP_011523410 XM_011525109 XP_011523411 NM_022066 NP_071349
Function	E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin- associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). {ECO:0000269|PubMed:23381138, ECO:0000269|PubMed:23452853,
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:24703950}. Nucleus {ECO:0000269|PubMed:24703950}. Note=Mainly localizes to the cytoplasm.
Tissue Specificity	Predominantly expressed in skeletal muscle and heart. {ECO:0000269|PubMed:11311559}.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human E2 230K full length protein - ab163749 from Abcam Category Protein Source Wheat germ Species Human

Human E2 230K full length protein - ab172183 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human E2 230K peptide - ab23233 from Abcam Category Peptide Species Human

Human E2 230K protein fragment - ab163750 from Abcam Category Protein Source Wheat germ Species Human

UBE2O Antibody Blocking Peptide - LS-E25474 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBE2O Antibody Blocking Peptide - LS-E21021 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UBE2O Protein - H00063893-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human UBE2O Protein - H00063893-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

UBE2O blocking peptide - GTX13728-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

UBE2O Blocking Peptide - 33R-10192 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

E2 230K Peptide - AC21-0303-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

UBE2O - H00063893-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UBE2O - H00063893-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UBE2O - H00063893-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UBE2O - H00063893-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

E2-230K Peptide - 45-512P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

UBE2O fusion protein - Ag8580 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human UBE2O, GST-tagged - UBE2O-162H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human UBE2O, His-tagged - UBE2O-3541H from Creative Biomart Category Protein Source E.coli Species Human

UBE2O protein-GST fusion - 009-001-U41 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

UBE2O protein-GST fusion - 009-001-U41S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

Recombinant Human Ubiquitin-conjugating enzyme E2 O(UBE2O) ,partial - CSB-YP866339HU CSB-EP866339HU CSB-BP866339HU CSB-MP866339HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

UBE2O - TP311950 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

E2-230K/UBE2O, Peptide - MBS426656 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

UBE2O Recombinant Protein Antigen - NBP2-13501PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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